Details of Disease | DrugMAP

General Information of Disease (ID: DISNCHV9)

Disease Name	Mixed phenotype acute leukemia
Synonyms	mixed phenotype acute leukemia; MPAL
Definition	An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage.
Disease Hierarchy	DISU70CB: Acute leukemia of ambiguous lineage DISNCHV9: Mixed phenotype acute leukemia
Disease Identifiers	MONDO ID MONDO_0020743 UMLS CUI C2826025 MedGen ID 417342 Orphanet ID 530995 SNOMED CT ID 1187123005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FLT3	TTGJCWZ	Strong	SomaticCausalMutation	[1]
KAT6A	TT6O1J0	Strong	Genetic Variation	[2]
P2RY8	TT84EWY	Strong	Biomarker	[3]
KMT2A	TT1GNDM	Definitive	Altered Expression	[4]
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This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS2	OTTK22NO	Strong	Biomarker	[5]
BCR	OTCN76C1	Strong	Biomarker	[4]
MLLT1	OT41UZU5	Strong	Genetic Variation	[6]
MLLT10	OTURMDV7	Strong	Biomarker	[7]
NCOA2	OTMQFPBB	Strong	Genetic Variation	[2]
TAF15	OTNE038N	Strong	Genetic Variation	[8]
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⏷ Show the Full List of 6 DOT(s)

References

1	Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls.Arch Pathol Lab Med. 2017 Nov;141(11):1462-1468. doi: 10.5858/arpa.2017-0218-RA.
2	MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2.Mol Cancer. 2007 Aug 13;6:51. doi: 10.1186/1476-4598-6-51.
3	Philadelphia Chromosome-like Mixed-Phenotype Acute Leukemia Demonstrating P2RY8-CRLF2 Fusion and JAK1 Mutation.Am J Clin Pathol. 2017 Nov 20;148(6):523-528. doi: 10.1093/ajcp/aqx111.
4	Mixed-phenotype acute leukemia characteristics: first report from Iran.Clin Exp Med. 2018 Nov;18(4):513-521. doi: 10.1007/s10238-018-0520-7. Epub 2018 Jul 17.
5	ADAMTS2 gene dysregulation in T/myeloid mixed phenotype acute leukemia.BMC Cancer. 2014 Dec 16;14:963. doi: 10.1186/1471-2407-14-963.
6	Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report.Am J Hematol. 2010 Jun;85(6):451-4. doi: 10.1002/ajh.21703.
7	CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice.Braz J Med Biol Res. 2019;52(6):e8424. doi: 10.1590/1414-431X20198424. Epub 2019 May 27.
8	Mixed Phenotype Acute Leukemia with t(12;17)(p13;q21)/TAF15-ZNF384 and Other Chromosome Abnormalities.Cytogenet Genome Res. 2016;149(3):165-170. doi: 10.1159/000448447. Epub 2016 Sep 9.