Details of Disease

General Information of Disease (ID: DISNHKHK)

• Disease Name: Specific learning disability
• Synonyms: specific learning difficulty; specific learning disorder
• Definition: Diagnosed when there are specific deficits in an individualbs ability to perceive or process information efficiently and accurately. This disorder first manifests during the years of formal schooling and is characterized by persistent and impairing difficulties with learning foundational academic skills in reading, writing, and/or math. The individualbs performance of the affected academic skills is well below average for age, or acceptable performance levels are achieved only with extraordinary effort. Specific learning disorder may occur in individuals identified as intellectually gifted and manifest only when the learning demands or assessment procedures (e.g., timed tests) pose barriers that cannot be overcome by their innate intelligence and compensatory strategies. For all individuals, specific learning disorder can produce lifelong impairments in activities dependent on the skills, including occupational performance. (from dsm-V)
• Disease Hierarchy:
  DISCFBRD: Neurological disorder
  DISNHKHK: Specific learning disability
• Disease Identifiers:
  MONDO ID: MONDO_0016225
  UMLS CUI: C4025790
  MedGen ID: 871302
  HPO ID: HP:0001328
  Orphanet ID: 211047

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATP5F1D	OTXTAG2V	Strong	CausalMutation	[1]

References

• [1] Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. Am J Hum Genet. 2018 Mar 1;102(3):494-504. doi: 10.1016/j.ajhg.2018.01.020. Epub 2018 Feb 22.