Details of Disease | DrugMAP

General Information of Disease (ID: DISOB289)

Disease Name	Obsolete autosomal recessive nail dysplasia
Definition	OBSOLETE. Autosomal recessive nail dysplasia is a rare, isolated nail anomaly characterized by claw-shaped, thick, hyperplastic, hard and hyperpigmented nails, subungual hyperkeratosis, onycholysis and slow nail growth. Variable degree of disease severity has been reported. [Orphanet:280654]
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DISOB289: Obsolete autosomal recessive nail dysplasia

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FZD6	OTBCPII8	Definitive	Autosomal recessive	[1]
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References

1	Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. Am J Hum Genet. 2011 Jun 10;88(6):852-860. doi: 10.1016/j.ajhg.2011.05.013.