Details of Disease | DrugMAP

General Information of Disease (ID: DISOVY34)

Disease Name	Autosomal dominant nonsyndromic hearing loss 56
Synonyms	autosomal dominant nonsyndromic deafness type 56; DFNA56; deafness, autosomal dominant type 56; autosomal dominant nonsyndromic deafness 56; autosomal dominant nonsyndromic deafness caused by mutation in TNC; autosomal dominant deafness 56; deafness, autosomal dominant 56; TNC autosomal dominant nonsyndromic deafness
Definition	Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the TNC gene.
Disease Hierarchy	DISYC1G0: Autosomal dominant nonsyndromic hearing loss DISOVY34: Autosomal dominant nonsyndromic hearing loss 56
Disease Identifiers	MONDO ID MONDO_0014283 UMLS CUI C3810170 OMIM ID 615629 MedGen ID 816500

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TNC	TTUCPMY	Moderate	Autosomal dominant	[1]
TNC	TTUCPMY	moderate	Biomarker	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TNC	OTK4FSHR	Moderate	Autosomal dominant	[1]
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References

1	Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. PLoS One. 2013 Jul 30;8(7):e69549. doi: 10.1371/journal.pone.0069549. Print 2013.