Details of Disease

General Information of Disease (ID: DISPDORC)

• Disease Name: Prostate hyperplasia
• Disease Class: GA90: Prostate hyperplasia
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISPDORC: Prostate hyperplasia
• ICD Code:
  ICD-11: ICD-11: GA90
  ICD-10: ICD-10: N40
  Expand ICD-11: 'GA90
  Expand ICD-10: 'N40
• Disease Identifiers:
  MONDO ID: MONDO_0010811
  MESH ID: D011470
  UMLS CUI: C1704272
  OMIM ID: 600082
  MedGen ID: 312369
  HPO ID: HP:0008711
  SNOMED CT ID: 266569009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Prostat	DM3VKMP	Approved	NA	[1]
THE-320	DMVEZGF	Approved	NA	[1]
Dihydrotestosterone	DM3S8XC	Phase 4	Small molecular drug	[2]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Finazosin	DML7UW5	Phase 3	NA	[3]
ProstaVac	DM5FZH4	Phase 3	Vaccine	[4]
ZANOTERONE	DM9HUYP	Phase 3	Small molecular drug	[5]
Erteberel	DMU1XZD	Phase 2	Small molecular drug	[6]

This Disease is Treated as An Indication in 9 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Antide	DMEO6PR	Discontinued in Phase 2	Small molecular drug	[7]
RBx-2258	DM7OD3J	Discontinued in Phase 2	NA	[8]
Taprizosin	DMF1VY4	Discontinued in Phase 2	Small molecular drug	[9]
Hormone-independent vaccine	DMJ13TF	Terminated	NA	[10]
L-757464	DM17S85	Terminated	NA	[11]
PPRT-321	DM5DYQV	Terminated	NA	[12]
R-1437	DMBU24I	Terminated	NA	[13]
SL-91.0893	DMJ9RLX	Terminated	NA	[14]
ZD-3980	DM91IPH	Terminated	NA	[15]

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ASC-JMX2	DMYJ87C	Investigative	NA	[16]
GTx-878	DMP9OGC	Investigative	NA	[17]
VLDM-01	DMZ129S	Investigative	NA	[16]
VTT-301	DMN57RI	Investigative	NA	[16]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2856).
• [3] Combination therapy with doxazosin and finasteride for benign prostatic hyperplasia in patients with lower urinary tract symptoms and a baseline to... J Urol. 2006 Jan;175(1):217-20; discussion 220-1.
• [4] Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer. Expert Opin Investig Drugs. 2009 July; 18(7): 1001-1011.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002570)
• [6] ClinicalTrials.gov (NCT01874756) The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia. U.S. National Institutes of Health.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3854).
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011920)
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017098)
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015100)
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051)
• [12] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010220)
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017122)
• [14] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007056)
• [15] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009538)
• [16] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621).