Details of Disease | DrugMAP

General Information of Disease (ID: DISQ205R)

Disease Name	Hyperpigmentation of the skin
Disease Hierarchy	DISWD40R: Disease DIS3BXY0: Skin pigmentation disorder DISQ205R: Hyperpigmentation of the skin
Disease Identifiers	MONDO ID MONDO_0019289 MESH ID D017495 UMLS CUI C0162834 MedGen ID 57992 HPO ID HP:0000953 Orphanet ID 79375 SNOMED CT ID 4830009

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AHR	TT037IE	Strong	Biomarker	[1]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC29A3	DTZAWTH	Strong	Biomarker	[2]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
RPL27A	OTQQHPL0	moderate	Biomarker	[3]
MYO5A	OTMWLP3E	Strong	Biomarker	[4]
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References

1	Aryl Hydrocarbon Receptor Activation Contributes to Benzanthrone-Induced Hyperpigmentation via Modulation of Melanogenic Signaling Pathways.Chem Res Toxicol. 2017 Feb 20;30(2):625-634. doi: 10.1021/acs.chemrestox.6b00364. Epub 2017 Jan 12.
2	Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease.PLoS Genet. 2010 Feb 5;6(2):e1000833. doi: 10.1371/journal.pgen.1000833.
3	Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.J Pathol. 2011 Aug;224(4):540-52. doi: 10.1002/path.2891. Epub 2011 Jun 14.
4	Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.J Invest Dermatol. 2008 Oct;128(10):2474-84. doi: 10.1038/jid.2008.100. Epub 2008 Apr 10.