Details of Disease

Disease Name

Disease Class

MB40: Sensation disturbance

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISQFDGF: Allodynia

ICD-11

ICD-11: MB40.1

Disease Identifiers

MONDO ID

MONDO_0014218

MESH ID

D006930

UMLS CUI

C3809719

OMIM ID

615508

MedGen ID

816049

HPO ID

HP:0012533

Orphanet ID

369992

SNOMED CT ID

774211005

General Information of Disease (ID: DISQFDGF)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
[3H]fenobam	DMBOXA1	Phase 1	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DSG1	OT11HC3A	Limited	Biomarker	[2]
DSP	OTB2MOP8	Limited	Genetic Variation	[3]
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References

1	ClinicalTrials.gov (NCT01981395) Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers. U.S. National Institutes of Health.
2	The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAMSyndrome.J Invest Dermatol. 2020 Mar;140(3):556-567.e9. doi: 10.1016/j.jid.2019.08.433. Epub 2019 Aug 26.
3	Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome caused by de novo mutation in the DSP gene misdiagnosed as generalized pustular psoriasis and treatment of acitretin with gabapentin.J Dermatol. 2019 Jul;46(7):622-625. doi: 10.1111/1346-8138.14925. Epub 2019 May 20.