Details of Disease | DrugMAP

General Information of Disease (ID: DISQQ9QA)

Disease Name	Pigmented nodular adrenocortical disease, primary, 1
Synonyms	pigmented micronodular adrenocortical disease, primary, 1; PPNAD1; adrenocortical nodular dysplasia, primary; Cushing syndrome, adrenal, due to PPNAD1; pigmented nodular adrenocortical disease, primary, 1; PRKAR1A primary pigmented nodular adrenocortical disease; pigmented nodular adrenocortical disease, primary, type 1; primary pigmented nodular adrenocortical disease caused by mutation in PRKAR1A
Definition	Any primary pigmented nodular adrenocortical disease in which the cause of the disease is a mutation in the PRKAR1A gene.
Disease Hierarchy	DISXCNDR: Primary pigmented nodular adrenocortical disease DISQQ9QA: Pigmented nodular adrenocortical disease, primary, 1
Disease Identifiers	MONDO ID MONDO_0012509 MESH ID C566469 UMLS CUI C1864846 OMIM ID 610489 MedGen ID 400627

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PRKAR1A	TTNAHEX	Strong	Autosomal dominant	[1]
PRKAR1A	TTNAHEX	Strong	Biomarker	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PRKAR1A	OT589JA2	Strong	Autosomal dominant	[1]
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References

1	Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab. 2002 Sep;87(9):4324-9. doi: 10.1210/jc.2002-020592.