General Information of Disease (ID: DISRVQAA)

Disease Name Ovarian granulosa cell tumor
Synonyms
granulosa theca cell tumour of the ovary; adult granulosa cell tumor of the ovary; granulosa theca cell tumor; GCT of the ovary; adult granulosa cell tumour of the ovary; granulosa theca cell tumour; granulosa theca cell tumor of the ovary; ovarian granulosa cell tumor; ovary granulosa cell tumour; granulosa cell tumor of ovary; granulosa cell neoplasm of ovary; granulosa cell neoplasm of the ovary; granulosa cell tumour of the ovary; ovarian granulosa cell neoplasm; granulosa cell tumor of the ovary; ovary granulosa cell tumor; granulosa cell tumour of ovary
Definition
A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis.
Disease Hierarchy
DISMSB18: Ovarian sex cord-stromal tumor
DISKWVAB: Granulosa cell tumor
DISRVQAA: Ovarian granulosa cell tumor
Disease Identifiers
MONDO ID
MONDO_0023283
MESH ID
C537296
UMLS CUI
C1370419
MedGen ID
277970

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
INTS13 OTWE6180 Limited Genetic Variation [1]
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References

1 Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus.Mamm Genome. 2013 Feb;24(1-2):63-71. doi: 10.1007/s00335-012-9439-6. Epub 2012 Nov 18.