Details of Disease

General Information of Disease (ID: DISTCV24)

Disease Name Thyroiditis
Synonyms thyroiditis (disease); thyroiditis; thyroid gland inflammation; inflammation of thyroid gland
Definition Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis.
Disease Hierarchy
DISWD40R: Disease
DIS5T3X5: Thyroid disease
DIS184KT: Skin inflammation
DISTCV24: Thyroiditis
Disease Identifiers
MONDO ID
MONDO_0004126
MESH ID
D013966
UMLS CUI
C0040147
MedGen ID
21548
HPO ID
HP:0100646
SNOMED CT ID
82119001

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
FOXP3 TT1X3QF Limited Biomarker [1]
TPO TT52XDZ Strong Biomarker [2]
TSHR TT6NYJA Strong Biomarker [3]
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This Disease Is Related to 7 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SSB OTCCTPBR moderate Biomarker [4]
ATN1 OTNZFLKY Strong Genetic Variation [5]
H2AC18 OTCE5JC7 Strong Biomarker [6]
H2AC20 OTEIVLM1 Strong Biomarker [6]
RNF112 OT0Q9OUQ Strong Biomarker [7]
RPL37 OTB6SDZ1 Strong Genetic Variation [8]
TG OT3ELHIJ Strong Biomarker [9]
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⏷ Show the Full List of 7 DOT(s)

References

1 Chronic lymphocytic thyroiditis (CLT) has a positive prognostic value in papillary thyroid cancer (PTC) patients: the potential key role of Foxp3+T lymphocytes.J Endocrinol Invest. 2018 Jun;41(6):703-709. doi: 10.1007/s40618-017-0794-8. Epub 2017 Dec 11.
2 Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology.Korean J Intern Med. 2019 Nov;34(6):1287-1296. doi: 10.3904/kjim.2017.177. Epub 2018 Mar 13.
3 A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.Thyroid. 2019 Aug;29(8):1138-1146. doi: 10.1089/thy.2019.0260. Epub 2019 Jul 3.
4 Autoimmunity and extranodal lymphocytic infiltrates in lymphoproliferative disorders.J Intern Med. 1999 Mar;245(3):277-86. doi: 10.1046/j.1365-2796.1999.0443f.x.
5 A transgenic mouse that spontaneously develops pathogenic TSH receptor antibodies will facilitate study of antigen-specific immunotherapy for human Graves' disease.Endocrine. 2019 Nov;66(2):137-148. doi: 10.1007/s12020-019-02083-9. Epub 2019 Sep 27.
6 H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis.J Immunol. 2005 Mar 1;174(5):3111-6. doi: 10.4049/jimmunol.174.5.3111.
7 Biologic false-positive serologic tests for syphilis and other serologic abnormalities in autoimmune hemolytic anemia and thrombocytopenic purpura.Medicine (Baltimore). 1989 Mar;68(2):67-84. doi: 10.1097/00005792-198903000-00001.
8 Coexistent thyroiditis is associated with lower tumour stage in thyroid carcinoma.Eur J Clin Invest. 1998 Oct;28(10):838-44. doi: 10.1046/j.1365-2362.1998.00363.x.
9 miRNA-125a modulates autophagy of thyroiditis through PI3K/Akt/mTOR signaling pathway.Exp Ther Med. 2019 Apr;17(4):2465-2472. doi: 10.3892/etm.2019.7256. Epub 2019 Feb 12.