Details of Disease

General Information of Disease (ID: DISTTZOD)

• Disease Name: Pleural mesothelioma
• Synonyms: pleural mesothelioma (disease), benign; benign pleural mesothelioma; pleural mesothelioma (disease); pleural mesothelioma; pleura mesothelioma; mesothelioma of the pleura; mesothelioma of pleura
• Disease Class: 2C26: Pleural mesothelioma
• Definition: A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath.
• Disease Hierarchy:
  DISKWK9M: Mesothelioma
  DISQSIBF: Pleural neoplasm
  DISTTZOD: Pleural mesothelioma
• ICD Code:
  ICD-11: ICD-11: 2C26.0
  Expand ICD-11: '2C26.0
  Expand ICD-10: 'C45-C49; 'C45; 'C45.0; 'C45.7
• Disease Identifiers:
  MONDO ID: MONDO_0003308
  UMLS CUI: C1377913
  MedGen ID: 237179

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Hu-CART meso cells	DM9VB4I	Phase 1	CAR T Cell Therapy	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MSLN	TT4RXME	Limited	Biomarker	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BST1	OTAV5SE7	Strong	Biomarker	[3]

References

• [1] ClinicalTrials.gov (NCT03054298) CAR T Cells in Mesothelin Expressing Cancers
• [2] Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.Eur J Surg Oncol. 2018 Jun;44(6):792-798. doi: 10.1016/j.ejso.2018.02.010. Epub 2018 Feb 17.
• [3] CD157: From immunoregulatory protein to potential therapeutic target.Immunol Lett. 2019 Jan;205:59-64. doi: 10.1016/j.imlet.2018.06.007. Epub 2018 Jun 21.