General Information of Disease (ID: DISTY5YZ)

Disease Name Squamous cell anal carcinoma
Synonyms
ANSC; squamous cell carcinoma of anus; squamous cell carcinoma of the anus; anal squamous cell carcinoma; epidermoid anal carcinoma; anus squamous cell carcinoma; epidermoid carcinoma of the anus; anal squamous cell cancer; squamous cell carcinoma - anus; squamous cell anal carcinoma; epidermoid carcinoma of anus
Disease Class 2C00: Anal cancer
Definition
A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC.
Disease Hierarchy
DISQUZFO: Anal cancer
DIS22NLK: Squamous cell carcinoma of rectum
DISQVIFL: Squamous cell carcinoma
DISTY5YZ: Squamous cell anal carcinoma
ICD Code
ICD-11
ICD-11: 2C00.3
ICD-9
ICD-9: 154.2, 154.3
Expand ICD-9
154.2,154.3
Disease Identifiers
MONDO ID
MONDO_0006082
UMLS CUI
C1412036
MedGen ID
237257

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
LY2606368 DM4XMF7 Phase 2 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PLK3 OT19CT2Z moderate Posttranslational Modification [2]
MACROH2A2 OTAKSVYV Strong Biomarker [3]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy.Oncotarget. 2016 Aug 16;7(33):53339-53349. doi: 10.18632/oncotarget.10801.
3 Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm.J Clin Pathol. 2016 Jul;69(7):627-31. doi: 10.1136/jclinpath-2015-203367. Epub 2015 Dec 10.