Details of Disease

Disease Name

Peyronie disease

Peyronie's disease; Peyronie disease; Induratio penis plastica; penis fibromatosis; penile induration; Peyronie's fibromatosis; penile fibromatosis

Definition

A condition characterized by hardening of the penis due to the formation of fibrous plaques on the dorsolateral aspect of the penis, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.

Disease Hierarchy

DISFKEQJ: Penile neoplasm

DISEUZDA: Superficial Fibromatosis

DIS8I9FS: Hereditary disorder of connective tissue

DIS7535C: Fibromatosis

DISUZ8RQ: Peyronie disease

Disease Identifiers

MONDO ID

MONDO_0008231

MESH ID

D010411

UMLS CUI

C0030848

OMIM ID

171000

MedGen ID

10629

Orphanet ID

2870

SNOMED CT ID

1335005

General Information of Disease (ID: DISUZ8RQ)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzoic Acid	DMKB9FI	Approved	Small molecular drug	[1]
Collagenase clostridium histolyticum	DM6L75O	Approved	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADORA2B	TTNE7KG	Limited	Biomarker	[3]
HDAC7	TTMUEK1	Limited	Biomarker	[4]
HDAC2	TTSHTOI	Strong	Altered Expression	[4]
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References

1	Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate. Int J Toxicol. 2017 Nov/Dec;36(3_suppl):5S-30S.
2	Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013 Jul;190(1):199-207.
3	Understanding the Role of Adenosine Receptors in the Myofibroblast Transformation in Peyronie's Disease.J Sex Med. 2018 Jul;15(7):947-957. doi: 10.1016/j.jsxm.2018.05.003. Epub 2018 Jun 8.
4	Silencing Histone Deacetylase 7 Alleviates Transforming Growth Factor-1-Induced Profibrotic Responses in Fibroblasts Derived from Peyronie's Plaque.World J Mens Health. 2018 May;36(2):139-146. doi: 10.5534/wjmh.170005.