Details of Disease

General Information of Disease (ID: DISVFYGY)

• Disease Name: Helicobacter infection
• Synonyms: infections, Helicobacter; infection, Helicobacter; Helicobacter infection; Helicobacter pylori infection, susceptibility to; Helicobacter pylori caused disease or disorder; Helicobacter pylori disease or disorder
• Disease Class: DA42-DA63: Helicobacter infection
• Definition: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
• Disease Hierarchy:
  DIS8MM3L: Gram-negative bacterial infection
  DISEM33Q: Infectious disease
  DISVFYGY: Helicobacter infection
• ICD Code:
  ICD-11: ICD-11: DA42-DA63
  ICD-10: ICD-10: B96.81
  ICD-9: ICD-9: 41.86
  Expand ICD-9: 41.86
• Disease Identifiers:
  MONDO ID: MONDO_0006781
  MESH ID: D016481

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
13C-urea	DMDYUH6	Approved	NA	[1]
14C-urea	DMLRYSQ	Approved	NA	[1]
Polaprezinc	DM1OC6A	Approved	Small molecular drug	[1]
Vonoprazan	DMO6315	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Helicobacter pylori vaccine	DMOHVK3	Phase 1	NA	[3]

This Disease is Treated as An Indication in 6 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NE-0080	DM92R9L	Discontinued in Phase 2	NA	[4]
E-3309	DMBN1UD	Discontinued in Phase 1	NA	[5]
Helivax	DM91PCQ	Discontinued in Phase 1	NA	[6]
FR-180102	DMD7B1W	Terminated	Small molecular drug	[7]
H pylori vaccine	DMT2R9F	Terminated	NA	[8]
Helicobacter vaccine	DMM9L12	Terminated	NA	[9]

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ARH-1029	DM8NETP	Investigative	NA	[10]
HelicoVax	DMIYZ21	Investigative	NA	[11]
HPy-HP 097	DMK83O8	Investigative	NA	[11]
TG-44	DM8P54B	Investigative	NA	[11]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2008
• [3] ClinicalTrials.gov (NCT00736476) Efficacy and Safety of an H.Pylori Vaccine in H.Pylori-Negative Adults. U.S. National Institutes of Health.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005552)
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016640)
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007830)
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011195)
• [8] The current status of Helicobacter pylori vaccines: a review. Helicobacter. 2007 Apr;12(2):89-102.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008115)
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849).
• [11] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.