Details of Disease

General Information of Disease (ID: DISVNBSJ)

Disease Name Motor peripheral neuropathy
Synonyms neuropathic muscular atrophy; hereditary motor and sensory neuropathy; HSMN - hereditary sensory and motor neuropathy; HSMN; peripheral motor neuropathy
Definition Inflammation or degeneration of the peripheral motor nerves.
Disease Hierarchy
DIS7KN5G: Peripheral neuropathy
DISVNBSJ: Motor peripheral neuropathy
Disease Identifiers
MONDO ID
MONDO_0002316
MESH ID
D011115
UMLS CUI
C0271683
MedGen ID
82885
HPO ID
HP:0007178
SNOMED CT ID
85423005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
TTR TTPOYU7 Limited Biomarker [1]
EPO TTQG4NR Strong Therapeutic [2]
PNPLA6 TTWAQU2 Strong Biomarker [3]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
IGHMBP2 OTAZFPF5 Strong Biomarker [4]
SCP2 OTPAFCPQ Definitive Biomarker [5]
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References

1 TTR-familial amyloid polyneuropathy--neurological aspects.Amyloid. 2012 Jun;19 Suppl 1:25-7. doi: 10.3109/13506129.2012.673182.
2 Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration. Neurobiol Dis. 2006 Dec;24(3):525-30. doi: 10.1016/j.nbd.2006.08.014. Epub 2006 Sep 28.
3 Mechanisms for consideration for intervention in the development of organophosphorus-induced delayed neuropathy.Chem Biol Interact. 2012 Sep 30;199(3):177-84. doi: 10.1016/j.cbi.2012.07.002. Epub 2012 Jul 20.
4 Diaphragmatic weakness with progressive sensory and motor polyneuropathy: case report of a neonatal IGHMBP2-related neuropathy.J Child Neurol. 2013 Jun;28(6):787-90. doi: 10.1177/0883073812450209. Epub 2012 Jul 12.
5 Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy. Am J Hum Genet. 2006 Jun;78(6):1046-52. doi: 10.1086/503921. Epub 2006 Mar 29.