Details of Disease

General Information of Disease (ID: DISW4CJG)

• Disease Name: Autosomal recessive nonsyndromic hearing loss 21
• Synonyms: autosomal recessive nonsyndromic deafness 21; DFNB21; autosomal recessive deafness 21; TECTA autosomal recessive nonsyndromic deafness; autosomal recessive nonsyndromic deafness caused by mutation in TECTA; deafness, autosomal recessive 21; tecta autosomal recessive nonsyndromic deafness; autosomal recessive nonsyndromic deafness type 21; autosomal recessive nonsyndromic deafness caused by mutation in tecta; deafness, autosomal recessive type 21; autosomal recessive nonsyndromic hearing loss 21
• Definition: Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the TECTA gene.
• Disease Hierarchy:
  DIS8G9R9: Hearing loss, autosomal recessive
  DISW4CJG: Autosomal recessive nonsyndromic hearing loss 21
• Disease Identifiers:
  MONDO ID: MONDO_0011351
  MESH ID: C566353
  UMLS CUI: C1863655
  OMIM ID: 603629
  MedGen ID: 355030

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TECTA	OT5E0NE2	Strong	Autosomal recessive	[1]

References

• [1] A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron. 2000 Oct;28(1):273-85. doi: 10.1016/s0896-6273(00)00102-1.