Details of Disease
General Information of Disease (ID: DISX4BM4)
| Disease Name | Isolated congenital anonychia | ||||
|---|---|---|---|---|---|
| Synonyms | congenital anonychia; autosomal recessive nonsyndromic congenital nail disorder-4; nonsyndromic congenital nail disorder, 4; isolated anonychia | ||||
| Definition |
Isolated congenital anonychia is characterized by nail abnormalities ranging from onychodystrophy (dystrophic nails) to anonychia (absence of nails). Onychodystrophy-anonychia has been described in at least four generations of a family with male-to-male transmission, suggesting autosomal dominant transmission. Anonychia has been described in approximately less than 20 cases; it is likely to be transmitted as an autosomal recessive trait. Total anonychia congenita, in which all the fingernails and toenails are absent, may have an autosomal dominant inheritance pattern.
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