Details of Disease

General Information of Disease (ID: DISZBO2J)

Disease Name Wet age-related macular degeneration
Disease Class 9B71: Retinopathy
Disease Hierarchy
DIS01GPL: Grass pollen hypersensitivity
DISZBO2J: Wet age-related macular degeneration
ICD Code
ICD-11
ICD-11: 9B78.3Z
ICD-10
ICD-10: H35.31
Disease Identifiers
MONDO ID
MONDO_0005150
MESH ID
D008268
UMLS CUI
C0242383
MedGen ID
116576
Orphanet ID
279
SNOMED CT ID
267718000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Brolucizumab DMW8QNG Approved Antibody [1]
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This Disease is Treated as An Indication in 6 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ADVM-022 DMS0CFO Phase 3 Gene therapy [2]
HMR59 DMMQZ3I Phase 2 Gene therapy [3]
RGX-314 DMVOJNP Phase 2 Gene therapy [4]
BI 836880 DMRI6YT Phase 1 Antibody [5]
hESC-derived RPE (PF-05206388) DM4TKAT Phase 1 Human embryonic stem (hES) cell-derived therapeutics [6]
iPSC-derived RPE (autologous) DM2LFZD Phase 1 Human embryonic stem (hES) cell-derived therapeutics [7]
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⏷ Show the Full List of 6 Drug(s)
This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
SPHINX31 DMYZQKC Preclinical Small molecular drug [8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 Clinical pipeline report, company report or official report of Adverum Biotechnologies.
3 ClinicalTrials.gov (NCT04358471) Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA). U.S. National Institutes of Health.
4 ClinicalTrials.gov (NCT04832724) RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD). U.S. National Institutes of Health.
5 ClinicalTrials.gov (NCT03861234) A Study to Test Different Doses of BI 836880 in Patients With an Eye Disease Called Wet Age-related Macular Degeneration (wAMD). U.S. National Institutes of Health.
6 ClinicalTrials.gov (NCT01691261) A Study Of Implantation Of Retinal Pigment Epithelium In Subjects With Acute Wet Age Related Macular Degeneration
7 Japan stem-cell trial stirs envy. Nature. 2014 Sep 18;513(7518):287-8.
8 Kinase inhibitors: the road ahead. Nat Rev Drug Discov. 2018 May;17(5):353-377.