Details of Disease

Disease Name

Nausea and vomiting

Disease Class

MD90: Nausea/vomiting

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISZBU97: Nausea and vomiting

ICD-11

ICD-11: MD90

ICD-10

ICD-10: R11

Expand ICD-11

'MD90

Expand ICD-10

'R11

Expand ICD-9

787787

Disease Identifiers

MedGen ID

45015

HPO ID

HP:0002017

SNOMED CT ID

16932000

General Information of Disease (ID: DISZBU97)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Granisetron	DMIUW25	Approved	Small molecular drug	[1]
Methscopolamine Bromide	DMHP8FI	Approved	Small molecular drug	[1]
Ramosetron	DMH7GN8	Approved	Small molecular drug	[2]
Trimethobenzamide	DMPP4DT	Approved	Small molecular drug	[1]
Y-25130	DMDPM7R	Approved	Small molecular drug	[3]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
TAK-951	DMHTIBR	Phase 2	NA	[4]
ADR-851	DM6NUCA	Phase 1	Small molecular drug	[5]
TAK-105	DMN03YW	Phase 1	NA	[6]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
HSR-113	DMGPH0B	Discontinued in Phase 1	NA	[7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2301).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2285).
4	ClinicalTrials.gov (NCT04557189) A Randomized Double-Blind, Sponsor-Open, Double-Dummy, Proof of Concept Phase 2 Study to Evaluate the Efficacy and Safety of TAK-951 Versus Ondansetron in the Prophylaxis of Postoperative Nausea and Vomiting in High-Risk Subjects. U.S.National Institutes of Health.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001323)
6	ClinicalTrials.gov (NCT04964258) A Randomized, Double-Blind, Sponsor-Open, Placebo-Controlled, Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TAK-105 in Healthy Subjects. U.S.National Institutes of Health.
7	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009786)