General Information of Drug-Metabolizing Enzyme (DME) (ID: DE05IKP)

DME Name Hydroxyacylglutathione hydrolase (HAGH)
Synonyms Glyoxalase II; Mitochondrial hydroxyacylglutathione hydrolase; GLO2; Glx II; HAGH; HAGH1
Gene Name HAGH
UniProt ID
GLO2_HUMAN
INTEDE ID
DME0603
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
3029
EC Number EC: 3.1.2.6
Hydrolases
Ester bond hydrolase
Thioester hydrolase
EC: 3.1.2.6
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDN
YMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESG
LKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFT
GDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAA
IREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREK
DQFKMPRD
Function This enzyme catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
KEGG Pathway
Metabolic pathways (hsa01100 )
Pyruvate metabolism (hsa00620 )
Reactome Pathway
Pyruvate metabolism [Q16775-2] (R-HSA-70268 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
methylglyoxal DMRC3OZ Discovery agent N.A. Investigative [1]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 6.13E-29 -1.01E+00 -1.69E+00
Alzheimer's disease 8A20 Entorhinal cortex 2.74E-07 -2.63E-01 -8.94E-01
Asthma CA23 Nasal and bronchial airway 1.29E-01 -8.09E-02 -2.25E-01
Behcet's disease 4A62 Peripheral blood 6.82E-01 3.39E-02 1.30E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 8.02E-02 -1.52E-02 -4.02E-02
Bladder cancer 2C94 Bladder tissue 4.64E-02 -1.39E-01 -6.19E-01
Breast cancer 2C60-2C6Z Breast tissue 1.03E-20 3.37E-01 5.49E-01
Colon cancer 2B90 Colon tissue 9.06E-11 -1.70E-01 -6.00E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.45E-01 8.57E-02 2.56E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 3.63E-01 7.76E-02 3.56E-01
Gastric cancer 2B72 Gastric tissue 5.93E-01 -4.19E-01 -8.96E-01
Glioblastopma 2A00.00 Nervous tissue 7.33E-151 -9.58E-01 -2.24E+00
Head and neck cancer 2D42 Head and neck tissue 1.25E-11 -4.26E-01 -8.44E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 9.48E-01 2.23E-02 4.63E-02
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 7.62E-01 -1.72E-02 -5.53E-02
Interstitial cystitis GC00.3 Bladder tissue 2.87E-01 -6.24E-02 -3.35E-01
Ischemic stroke 8B11 Peripheral blood 2.01E-01 1.03E-01 7.03E-01
Liver cancer 2C12.0 Liver tissue 3.70E-11 -7.63E-01 -1.31E+00
Liver failure DB99.7-DB99.8 Liver tissue 7.70E-05 -1.47E+00 -2.47E+00
Lung cancer 2C25 Lung tissue 9.07E-17 -2.58E-01 -1.12E+00
Lupus erythematosus 4A40 Whole blood 2.15E-10 -6.03E-01 -9.10E-01
Major depressive disorder 6A70-6A7Z Hippocampus 8.59E-01 2.42E-02 6.40E-02
Multiple myeloma 2A83.1 Bone marrow 6.05E-05 8.18E-01 2.75E+00
Multiple myeloma 2A83.1 Peripheral blood 5.76E-01 -1.56E-01 -1.27E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.48E-01 -1.11E-01 -3.14E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.41E-02 2.42E-01 5.53E-01
Myocardial infarction BA41-BA50 Peripheral blood 5.14E-01 -3.80E-02 -3.03E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 4.31E-01 -1.44E-01 -4.51E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 2.40E-01 5.11E-02 1.85E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 3.61E-02 3.33E-01 2.02E+00
Olive pollen allergy CA08.00 Peripheral blood 7.76E-01 -1.16E-01 -1.57E-01
Oral cancer 2B6E Oral tissue 2.12E-06 -4.86E-01 -9.79E-01
Ovarian cancer 2C73 Ovarian tissue 1.61E-03 6.02E-01 1.58E+00
Pancreatic cancer 2C10 Pancreas 1.13E-02 -2.11E-01 -6.98E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 2.19E-01 3.90E-02 1.06E-01
Pituitary cancer 2D12 Pituitary tissue 8.66E-03 2.59E-01 9.00E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 2.40E-01 2.29E-01 7.96E-01
Pompe disease 5C51.3 Biceps muscle 2.74E-01 2.13E-01 8.58E-01
Prostate cancer 2C82 Prostate 6.34E-05 8.81E-01 1.45E+00
Psoriasis EA90 Skin 1.09E-05 1.39E-01 4.84E-01
Rectal cancer 2B92 Rectal colon tissue 9.16E-06 -3.92E-01 -3.83E+00
Renal cancer 2C90-2C91 Kidney 8.52E-03 -6.65E-01 -1.13E+00
Retinoblastoma 2D02.2 Uvea 2.06E-07 -9.23E-01 -5.18E+00
Schizophrenia 6A20 Prefrontal cortex 6.00E-04 -1.87E-01 -3.38E-01
Schizophrenia 6A20 Superior temporal cortex 3.69E-01 1.48E-02 5.91E-02
Scleroderma 4A42.Z Whole blood 2.03E-02 -2.37E-01 -6.95E-01
Seizure 8A60-8A6Z Whole blood 3.32E-01 -1.89E-01 -2.86E-01
Sepsis with septic shock 1G41 Whole blood 1.97E-20 -5.11E-01 -1.09E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.36E-02 1.64E-01 7.33E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 3.05E-01 6.09E-02 7.24E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 2.88E-04 -4.78E-01 -3.63E+00
Skin cancer 2C30-2C3Z Skin 9.30E-05 2.10E-01 5.30E-01
Thrombocythemia 3B63 Whole blood 3.39E-01 1.14E-01 3.24E-01
Thrombocytopenia 3B64 Whole blood 4.83E-01 2.64E-01 1.93E-01
Thyroid cancer 2D10 Thyroid 5.74E-02 6.03E-02 2.78E-01
Tibial muscular dystrophy 8C75 Muscle tissue 2.78E-03 -3.94E-01 -1.37E+00
Tuberous sclerosis complex LD2D.2 Perituberal tissue 9.95E-04 -8.33E-01 -4.66E+00
Type 2 diabetes 5A11 Liver tissue 4.74E-02 -2.56E-01 -1.12E+00
Ureter cancer 2C92 Urothelium 4.40E-01 1.89E-02 1.02E-01
Uterine cancer 2C78 Endometrium tissue 2.32E-06 -1.98E-01 -3.53E-01
Vitiligo ED63.0 Skin 3.27E-01 5.94E-02 5.37E-01
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⏷ Show the Full List of DME Expression Under 61 Diseases

References

1 Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder. Eur Child Adolesc Psychiatry. 2015 Jan;24(1):75-82.