General Information of Drug-Metabolizing Enzyme (DME) (ID: DE174E0)

DME Name Dextransucrase 2 (dsrF2)
Synonyms Glucansucrase 2; Sucrose 6-glucosyltransferase 2; Dextransucrase II; Dextransucrase DsrF; dsrF2
Gene Name dsrF
UniProt ID
GTF2_LEUME
INTEDE ID
DME1168
EC Number EC: 2.4.1.5
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.5
Lineage Species: Leuconostoc mesenteroides
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Leuconostocaceae
Genus: Leuconostoc
Species: Leuconostoc mesenteroides

Subspecies: Leuconostoc mesenteroides 0326
Tissue Distribution Primarily distributed in human gut.
Sequence
MRASPSQFFAISLLSIAISGLLSGAAVAAPAPAALEQVPDGKGGVKWQEVQADKPAEEEQ
EGKGRKKFLGIQAITTEPDGSVKVEMGKPEVRQPASGDVFVSNEKLDEHVIFQAFALYQP
NDNATYKALAENAPQLAQWGITDVWSPPPYRAASDSKYGEGYAIADRYDLGAYDKGPTKY
GTADELKAAIGALHNNDIRIQVDVVPNQIIGLNERHVLPVTGVDMYGKPMNPFLDHYLYS
TYSKGSAPGQAEHGVIKEWDYFHFHGTTTQYQGLFRVLSDANSKLYRYLGPNHPENYLPA
FLAESDAAKYGKINTIDGYLLADTWFAVENAESENAVYAPLFLYYEEPRSGVVEQTFMDF
ARENGYTGSDEDIRATMLAELRMTPNPLGPLMDEYLAAQPGYSKKSEDDAKVTALRYDGP
ENDASHIGTNVLDFEFLVGNDLDTIREDVQQEQLNWQKYLLDFGFDGFRIDAASHINTDM
LRDEVTQRLNYFAGEDVNEHLSYIESYVAQQVDFEQSNNYGQMAMDAGPFSGLMFSFGRD
WAPLRYAFEASLIDRVNGGPALPNWSFVNNHDQEHNILVTVPLTEEEAGGYEPNSQPYEL
RQLEKYDADRNSVEKQWAPHNVPAMYAILLTTRDTVPTVFYGDMFMSSKPYMSTPTPYRD
DIVNILKLRKQFAKGEQVIRYENSNTGSNGEDLVSNIRLGNDRKTGVAVVAGNNPALDTT
ITVDMGAQHRNQWFVDAMGYQPERLKTDKDGRLTVQVKGTQNVDVKGYLAAWVPDLQAQE
Function This enzyme involves in the production of dextran, an extracellular glucan polymer.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Caffeic acid phenethyl ester DMRJKIV Discovery agent N.A. Investigative [1]

References

1 Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512.