Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE1NJIW)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; PAU_00771; PA-RVA13-1244
Gene Name	ampC
UniProt ID	B6VMJ3_PHOAA
INTEDE ID	DME1314
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Photorhabdus asymbiotica Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Morganellaceae Genus: Photorhabdus Species: Photorhabdus asymbiotica
Tissue Distribution	Primarily distributed in human skin.
Sequence	MTKRFSVLTGSLLLAASLGVQASNTPDQTRLTNTVDKTIHSLMQEYDIPGMAIAVTFRGQ HFFYQYGDASKESNTPVTKETIFELGSVSKTFAGSLISWAQVTGAISFSDKASQHFQPLA GSAFDNINLLNIATYTAGGLPLQFPDEIDNNSKMVDWFQHWQPKYPPGTYRQYSNPSIGL AGYIVAQRLEKPYSILVKNQILSPLGLHHTWFNVPAQEMKNYALGYSKENKPIRINPGVL DEEAYGLKTSAQDLIGFVDANIDPSRVGDSKLAQAIRATHTGYYRTGEMTQGLGWELYHW PVTLEQVLSGNSAEIAYQANKTTELSPPEPPTDALFINKTGSTNGFGAYVAFVPQEQMGI VLLANKNYPNEARIKAAWQILKALK
Function	This enzyme hydrolyzes beta-lactam.
KEGG Pathway	Two-component system (pay02020 ) beta-Lactam resistance (pay01501 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1], [2]
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References

1	Yersinia enterocolitica and Photorhabdus asymbiotica beta-lactamases BlaA are exported by the twin-arginine translocation pathway. Int J Med Microbiol. 2013 Jan;303(1):16-24.
2	Xenorhabdus luminescens (DNA hybridization group 5) from human clinical specimens. J Clin Microbiol. 1989 Jul;27(7):1594-600. Case Reports