Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE235K6)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; HMPREF0351_10377; bglH
• Gene Name: bglH
• UniProt ID: Q3Y0M8_ENTFD
• INTEDE ID: DME2060
• Gene ID: 12999036
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Enterococcus faecium
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Bacilli
  Order: Lactobacillales
  Family: Enterococcaceae
  Genus: Enterococcus
  Species: Enterococcus faecium
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MDQEIFPENFLWGGAVAANQCEGAWLEDGKLPNVTDTLIGIMNQHPSIQWNEEKKIWEIA
  LDESLHYLSHEAIDFYHRFEEDIRLLKELGLKAFRTSISWARIFPRGDEQKPNEAGLVFY
  DRLINTLNRYDIEPVITLSHYETPLALVGEYGGWQNRKLIDFFEFYAQTVFERYQGKVKY
  WMTFNEINNAFRMPYAAAGLVTFPARDKLEPIATLTKKVIYQACHHMFLANARATQLLKK
  IDPNAKMGIMCSFSALATYAYDCDPENVFGSLQFKRNSWFFSDVMCRGHYPAYIYRTWKE
  EDCAPVMLDGDEQCLQANTADYIAFSYYRSAVYKKEAEMRVDTGGANGFDNPFLKEKSPE
  PWSWPIDPLGFRYVMNELTDRYELPLFIVENGIGLDEAPDELNRIHDPKRCEYLKIHLQE
  IAEAIKDGCQIIGYLWWGPIDIVSAGTGEMRKRYGFIYVDRQNDGSGSFRRLKKDSFEYY
  KQIIQSNGKNLEYRSFFK
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
• KEGG Pathway:
  Glycolysis / Gluconeogenesis (efu00010)
  Starch and sucrose metabolism (efu00500)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lactulose	DMSAOWQ	Constipation	DD91.1	Approved	[1]

References

• [1] In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.