General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2M583)

DME Name Endoglucanase Y (EGY)
Synonyms Endo-1,4-beta-glucanase Y; SGNH_hydro domain-containing protein Y; Cellulase Y; EGY; CBG24_05650
Gene Name EGY
UniProt ID
A0A256VAC0_LACRE
INTEDE ID
DME1641
EC Number EC: 3.2.1.136
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.136
Lineage Species: Lactobacillus gasseri
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus gasseri
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKYQPTDLIKFASRTGRWTIKKLDNSPTLYTTNLGSYLRFKVSDAKKCQITVLPNQNSL
SPSQVFAFRIDGGKWQRAQASLEKIDIPLDSTLHTIEIMAAGNTDIDEVWQGNEGFAIKN
IYLDRGEITAAPQRPLINFIGDSITAGCWVVGNHPAADYRPETNYAGICADLLNVDSVRI
AYSAGGVLRPATGGVPTADVFLGKIDNQTLWTPNHPDLNVINLGVNDRRFPLTQFIAAFD
LFIQQVKLTFPHTPLAIIIPFSQTFASAIRTIATKHDCSIIETKTWHHSFTDGLHPDQAG
AINEGKMLAQALQPLLPQFSVQ
Function This enzyme hydrolyzes 1,4-linkages in beta-D-glucans also containing 1,3-linkages.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
5 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bacitracin DM5OHYE Blepharoconjunctivitis Approved [1]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [1]
Gentamicin DMKINJO Bacteremia 1A73 Approved [1]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [1]
Streptomycin DME1LQN Bacterial infection 1A00-1C4Z Approved [1]

References

1 Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63.