Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE2ZWSM)

DME Name Aldehyde dehydrogenase 7 (ALDH7)
Synonyms Aldehyde dehydrogenase 3 family member B1; ALDH3B1; ALDH7
Gene Name ALDH3B1
UniProt ID
AL3B1_HUMAN
INTEDE ID
DME0294
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
221
EC Number EC: 1.2.1.5
Oxidoreductase
Aldehyde/oxo donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.2.1.5
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Function This enzyme oxidizes medium and long chain saturated and unsaturated aldehydes. It also metabolizes benzaldehyde and it has low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde.
KEGG Pathway
Chemical carcinogenesis (hsa05204 )
Drug metabolism - cytochrome P450 (hsa00982 )
Glycolysis / Gluconeogenesis (hsa00010 )
Histidine metabolism (hsa00340 )
Metabolic pathways (hsa01100 )
Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
Phenylalanine metabolism (hsa00360 )
Tyrosine metabolism (hsa00350 )
beta-Alanine metabolism (hsa00410 )
Reactome Pathway
Sphingolipid de novo biosynthesis (R-HSA-1660661 )
Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
3,4-dihydroxyphenylacetaldehyde DM7N3MX Discovery agent N.A. Investigative [1]
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
3,4-dihydroxyphenylacetaldehyde Discovery agent [N.A.] Investigative Km = 0.0004 microM [1]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.88E-06 -1.69E-01 -4.55E-01
Alopecia ED70 Skin from scalp 3.10E-01 -4.66E-02 -1.71E-01
Alzheimer's disease 8A20 Entorhinal cortex 1.52E-01 2.65E-02 1.72E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 4.37E-01 1.11E-01 5.35E-01
Aortic stenosis BB70 Calcified aortic valve 4.88E-01 1.76E-01 3.19E-01
Apnea 7A40 Hyperplastic tonsil 3.76E-01 -6.72E-04 -1.98E-03
Arthropathy FA00-FA5Z Peripheral blood 5.31E-01 1.14E-01 4.34E-01
Asthma CA23 Nasal and bronchial airway 9.65E-01 9.68E-02 1.06E-01
Atopic dermatitis EA80 Skin 9.87E-01 -1.28E-02 -8.73E-02
Autism 6A02 Whole blood 8.17E-01 7.78E-02 3.58E-01
Autoimmune uveitis 9A96 Peripheral monocyte 3.55E-02 -5.04E-01 -1.29E+00
Autosomal dominant monocytopenia 4B04 Whole blood 9.15E-01 6.66E-02 1.85E-01
Bacterial infection of gingival 1C1H Gingival tissue 5.63E-09 2.37E-01 1.04E+00
Batten disease 5C56.1 Whole blood 5.58E-01 -4.68E-02 -1.49E-01
Behcet's disease 4A62 Peripheral blood 5.55E-01 7.92E-02 2.52E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 4.03E-01 2.67E-02 1.25E-01
Bladder cancer 2C94 Bladder tissue 1.45E-02 2.69E-01 1.20E+00
Breast cancer 2C60-2C6Z Breast tissue 8.87E-01 -5.09E-02 -1.55E-01
Cardioembolic stroke 8B11.20 Whole blood 1.52E-01 -6.24E-02 -2.34E-01
Cervical cancer 2C77 Cervical tissue 4.70E-01 1.25E-01 3.10E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.25E-01 1.70E-01 4.33E-01
Chronic hepatitis C 1E51.1 Whole blood 9.66E-01 -1.61E-01 -3.74E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 5.64E-01 3.51E-03 1.01E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 5.95E-01 7.55E-02 1.19E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 4.30E-02 -6.73E-01 -1.04E+00
Colon cancer 2B90 Colon tissue 3.67E-01 6.44E-03 2.14E-02
Coronary artery disease BA80-BA8Z Peripheral blood 9.08E-01 -7.62E-02 -1.67E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 2.74E-01 8.22E-02 4.92E-01
Endometriosis GA10 Endometrium tissue 8.69E-02 1.14E-01 4.20E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 8.11E-01 -5.28E-02 -2.66E-01
Familial hypercholesterolemia 5C80.00 Whole blood 6.69E-05 4.07E-01 1.83E+00
Gastric cancer 2B72 Gastric tissue 9.08E-01 -1.44E-01 -4.36E-01
Glioblastopma 2A00.00 Nervous tissue 9.76E-02 2.08E-02 5.59E-02
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 8.01E-01 2.00E-02 1.42E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 3.21E-03 -8.00E-01 -1.48E+00
Head and neck cancer 2D42 Head and neck tissue 3.29E-13 -4.69E-01 -3.09E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 2.80E-01 -1.56E-01 -7.30E-01
Huntington's disease 8A01.10 Whole blood 2.74E-01 1.63E-01 2.58E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 8.55E-02 3.97E-01 1.05E+00
Immunodeficiency 4A00-4A20 Peripheral blood 6.21E-02 1.73E-01 1.52E+00
Influenza 1E30 Whole blood 2.39E-01 1.52E-01 3.47E+00
Interstitial cystitis GC00.3 Bladder tissue 1.98E-01 -1.99E-01 -9.33E-01
Intracranial aneurysm 8B01.0 Intracranial artery 2.01E-02 3.01E-01 1.22E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 5.95E-01 2.10E-02 8.50E-02
Ischemic stroke 8B11 Peripheral blood 6.19E-01 4.27E-02 1.97E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 5.93E-01 -2.03E-02 -4.56E-02
Lateral sclerosis 8B60.4 Skin 6.47E-01 4.12E-02 1.97E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 9.38E-02 8.58E-02 4.25E-01
Liver cancer 2C12.0 Liver tissue 5.18E-01 -1.40E-01 -4.70E-01
Liver failure DB99.7-DB99.8 Liver tissue 1.20E-02 2.39E-01 1.07E+00
Lung cancer 2C25 Lung tissue 3.08E-72 -1.11E+00 -2.37E+00
Lupus erythematosus 4A40 Whole blood 2.01E-01 2.27E-02 4.34E-02
Major depressive disorder 6A70-6A7Z Hippocampus 2.50E-01 -5.27E-02 -2.50E-01
Major depressive disorder 6A70-6A7Z Whole blood 4.50E-04 1.53E-01 5.70E-01
Melanoma 2C30 Skin 3.76E-01 6.09E-01 5.59E-01
Multiple myeloma 2A83.1 Peripheral blood 6.97E-01 2.35E-02 7.83E-02
Multiple myeloma 2A83.1 Bone marrow 2.15E-03 -2.28E-01 -1.68E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 2.85E-01 9.30E-02 4.61E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 9.73E-09 7.48E-01 2.08E+00
Myelofibrosis 2A20.2 Whole blood 7.22E-04 2.41E-01 9.68E-01
Myocardial infarction BA41-BA50 Peripheral blood 1.61E-03 7.89E-01 8.66E-01
Myopathy 8C70.6 Muscle tissue 3.09E-01 -8.82E-02 -4.19E-01
Neonatal sepsis KA60 Whole blood 9.98E-09 3.39E-01 7.76E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 8.41E-05 -9.17E-01 -2.33E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.83E-01 -2.91E-02 -2.73E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.90E-01 2.61E-01 1.09E+00
Olive pollen allergy CA08.00 Peripheral blood 1.45E-01 2.55E-01 8.97E-01
Oral cancer 2B6E Oral tissue 1.30E-06 -4.14E-01 -1.21E+00
Osteoarthritis FA00-FA0Z Synovial tissue 3.68E-01 1.16E-01 3.43E-01
Osteoporosis FB83.1 Bone marrow 9.35E-02 3.79E-01 3.81E+00
Ovarian cancer 2C73 Ovarian tissue 5.24E-01 1.11E-01 1.43E-01
Pancreatic cancer 2C10 Pancreas 7.18E-04 5.84E-01 1.34E+00
Parkinson's disease 8A00.0 Substantia nigra tissue 1.82E-01 -9.54E-02 -5.64E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 7.37E-04 3.95E-01 1.21E+00
Pituitary cancer 2D12 Pituitary tissue 3.88E-02 -2.99E-01 -1.27E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 1.71E-04 -4.06E-01 -2.90E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 8.83E-01 -2.72E-02 -1.31E-01
Polycythemia vera 2A20.4 Whole blood 1.13E-02 9.43E-02 3.76E-01
Pompe disease 5C51.3 Biceps muscle 4.61E-04 4.90E-01 1.68E+00
Preterm birth KA21.4Z Myometrium 4.35E-02 3.82E-01 2.15E+00
Prostate cancer 2C82 Prostate 7.61E-02 -1.87E-01 -3.85E-01
Psoriasis EA90 Skin 2.09E-07 -1.53E-01 -5.00E-01
Rectal cancer 2B92 Rectal colon tissue 1.63E-01 -4.49E-02 -1.73E-01
Renal cancer 2C90-2C91 Kidney 9.32E-01 -7.66E-02 -1.39E-01
Retinoblastoma 2D02.2 Uvea 5.15E-03 4.09E-01 3.12E+00
Rheumatoid arthritis FA20 Synovial tissue 3.30E-02 3.32E-01 8.74E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 7.38E-02 -1.42E-01 -3.93E-01
Schizophrenia 6A20 Prefrontal cortex 3.81E-02 1.83E-01 3.30E-01
Schizophrenia 6A20 Superior temporal cortex 2.78E-01 -4.31E-02 -3.75E-01
Scleroderma 4A42.Z Whole blood 8.62E-02 -9.20E-02 -4.77E-01
Seizure 8A60-8A6Z Whole blood 9.12E-01 -2.62E-02 -8.76E-02
Sensitive skin EK0Z Skin 2.66E-02 9.29E-02 8.19E-01
Sepsis with septic shock 1G41 Whole blood 3.79E-16 2.58E-01 6.94E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 8.52E-03 -2.41E-01 -1.58E+00
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 2.51E-02 1.53E-01 1.09E+00
Simpson golabi behmel syndrome LD2C Adipose tissue 8.20E-01 1.81E-02 3.95E-01
Sjogren's syndrome 4A43.2 Salivary gland tissue 7.02E-01 -6.26E-02 -2.29E-01
Skin cancer 2C30-2C3Z Skin 1.04E-03 9.17E-02 2.30E-01
Thrombocythemia 3B63 Whole blood 6.75E-02 5.89E-03 2.39E-02
Thrombocytopenia 3B64 Whole blood 2.88E-01 3.14E-01 5.07E-01
Thyroid cancer 2D10 Thyroid 1.98E-61 7.23E-01 2.84E+00
Tibial muscular dystrophy 8C75 Muscle tissue 4.39E-02 2.08E-01 8.94E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 9.55E-04 2.85E-01 3.53E+00
Type 2 diabetes 5A11 Liver tissue 8.32E-01 2.53E-02 1.46E-01
Ureter cancer 2C92 Urothelium 7.22E-01 -6.52E-02 -4.01E-01
Uterine cancer 2C78 Endometrium tissue 7.19E-18 -4.30E-01 -9.99E-01
Vitiligo ED63.0 Skin 4.05E-02 -2.92E-01 -1.10E+00
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.