Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE48UAX)

DME Name	Aminoglycoside 6'-N-acetyltransferase (aacA)
Synonyms	Aminoglycoside 6'-N-acetyltransferase type II AAC6'Ib; Aminoglycoside N-acetyltransferase; aac(6')-Ib
Gene Name	aac(6')-Ib
UniProt ID	C5MQW3_KLEPO
INTEDE ID	DME2057
EC Number	EC: 2.3.1.82 Transferase Acyltransferase Acyltransferase EC: 2.3.1.82
Lineage	Species: Klebsiella pneumoniae Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella pneumoniae
Tissue Distribution	Primarily distributed in human lung.
Sequence	MTEHDLAMLYEWLNRSHIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPI GYAQSYVALGSGDGWWEEETDPGVRGIDQSLANASQLGKGLGTKLVRALVELLFNDPEVT KIQTDPSPSNLRAIRCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSDA
Function	This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, kanamycin, tobramycin and netilmicin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacterial infection	1A00-1C4Z	Approved	[1]
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References

1	Detection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil. Biomedica. 2019 May 1;39(s1):135-149.