Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE4LKZ9)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; DEW10_04450
• Gene Name: DEW10_04450
• UniProt ID: A0A3D1ZWL4_9BIFI
• INTEDE ID: DME1146
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Bifidobacterium dentium
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Bifidobacteriales
  Family: Bifidobacteriaceae
  Genus: Bifidobacterium
  Species: Bifidobacterium dentium
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MAVILPAMLASCSAPGFSASAHHEAVRRSNAMSGTLDREKTPAANTDASSHDKAVKAVEA
  MSMQERVGQLVMAPLYAGSDPSTLQHLIADQHVGSVLVIGNCTSGTAGVAAATAALQSYA
  PANDQLLMATDQEGGQVQHLQGSGFDRMPSAVDQGRMTTDTLRESAAVWGSQLKSAGINV
  DLAPVVGTVTVDRASNDPVGALNRDFGLDAAGNAEHAKAFIEGMADSGVGSAIKHYPGLG
  SVTGNTDFTAEGTLDTTTTLDGAEIGAFNEALRANPSMVMMALATYQAIDPNNPAVFSST
  LITDYLRGTIGFQGVITSDSMSAAALSGIEPADLGVRLVEAGGDLACIGSSDYVQPVLDG
  LNAKAAADASFAQKVTQSAIRVMTLKYDMGLAR
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[1]

1 Preclinical Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HY-N0040	DM349AM	N. A.	N. A.	Preclinical	[1]

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]

References

• [1] Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.