Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5NSUX)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; HMPREF1639_06800
Gene Name	HMPREF1639_06800
UniProt ID	A0A095XPV0_9FIRM
INTEDE ID	DME1485
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Peptostreptococcus anaerobius Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Peptostreptococcaceae Genus: Peptostreptococcus Species: Peptostreptococcus anaerobius
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MKKIVILSCFIAFAFVVLFPRSFIFAAEETEHYETVIDKVADAYIGKSVPGACVIVSEHG EIVFSKAYGYADLEKNIPMDPENTVFEWGSISKTFIWVGVMQLNEEGKIDLDADIRNYLP KGFLKNLHYDTPITMRHLMNHTAGFEEQLINLRYFESDKEFTLAEVLSSHQPEQVFSPGK VSAYSNWGAALAAFIVERVSGQNYKEYVNEHILKPLDMNNTSIGPFQNDNPTILARKAVG YSFFEKGFRKEPNMYLRMYPAGGMNGSAGDLLNYAQELAKNNDKDNLLFNNPHTKKEMFT ETYRSYGANSGLSHGFWQYANNPEMHGHEGGTYGFKTQIWVEPKNERAILILTNVMETEF CSEIMEKIAYTEADEKKIKENLDLKMLSGDYLPARSALKNVGKIQGKKQMISIRVTDGNR LCLTMPFEDKKQYYEQIDSNIFFCKDASPEEKILAFNINDGKVHSMSFRLAHDYIPATNT QGKIAFLFSLGTYISTTLLFLTLLIICIISTLQRWKRCMRHHIYLYICGAMLGISGITGM AHWFSIYEILAHELMIIIIAGWCFSIIGILCGGYAIFKERSIKNSGLLLIFIAQIFSAYY LGFLTVV
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.