Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE69QHT)

DME Name Aminoglycoside acetyltransferase (aac)
Synonyms Aminoglycoside 2'-N-acetyltransferase; AAC(2')-Ia; aac
Gene Name aac
UniProt ID
AAC2_PROST
INTEDE ID
DME1141
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
31518288
EC Number EC: 2.3.1.59
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.59
Lineage Species: Providencia stuartii
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Providencia
Species: Providencia stuartii
Tissue Distribution Primarily distributed in human gut.
Sequence
MGIEYRSLHTSQLTLSEKEALYDLLIEGFEGDFSHDDFAHTLGGMHVMAFDQQKLVGHVA
IIQRHMALDNTPISVGYVEAMVVEQSYRRQGIGRQLMLQTNKIIASCYQLGLLSASDDGQ
KLYHSVGWQIWKGKLFELKQGSYIRSIEEEGGVMGWKADGEVDFTASLYCDFRGGDQW
Function This enzyme catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Plazomicin DMKMBES Bronchitis CA20 Approved [1]

References

1 Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987.