Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE76G8C)

DME Name S-adenosylmethionine synthase 2 (MAT2A)
Synonyms Methionine adenosyltransferase 2; AdoMet synthase 2; Methionine adenosyltransferase II; S-adenosylmethionine synthase isoform type-2; AMS2; MAT 2; MAT-II; MAT2A; MATA2
Gene Name MAT2A
UniProt ID
METK2_HUMAN
INTEDE ID
DME0190
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
4144
EC Number EC: 2.5.1.6
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.6
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
Function
This enzyme catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
KEGG Pathway
Biosynthesis of amino acids (hsa01230 )
Cysteine and methionine metabolism (hsa00270 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Methylation (R-HSA-156581 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-methionine DME8G1U Discovery agent N.A. Investigative [2]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 1.49E-01 9.01E-02 1.47E-01
Alopecia ED70 Skin from scalp 5.70E-01 -2.57E-02 -1.08E-01
Alzheimer's disease 8A20 Entorhinal cortex 5.54E-04 1.30E-01 4.15E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 2.33E-01 3.22E-01 8.25E-01
Aortic stenosis BB70 Calcified aortic valve 4.60E-01 -2.56E-01 -4.02E-01
Apnea 7A40 Hyperplastic tonsil 8.53E-02 -3.09E-01 -4.25E-01
Arthropathy FA00-FA5Z Peripheral blood 2.38E-03 -1.54E-01 -7.28E-01
Asthma CA23 Nasal and bronchial airway 3.25E-02 1.93E-02 3.21E-02
Atopic dermatitis EA80 Skin 2.84E-01 -6.57E-04 -1.34E-03
Autism 6A02 Whole blood 2.02E-01 -8.20E-02 -1.93E-01
Autoimmune uveitis 9A96 Peripheral monocyte 2.16E-01 1.64E-01 6.25E-01
Autosomal dominant monocytopenia 4B04 Whole blood 3.45E-01 -3.03E-01 -4.53E-01
Bacterial infection of gingival 1C1H Gingival tissue 1.19E-01 1.46E-01 3.58E-01
Batten disease 5C56.1 Whole blood 4.58E-01 -1.71E-01 -1.12E+00
Behcet's disease 4A62 Peripheral blood 6.44E-01 -5.07E-02 -1.26E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 7.88E-01 -1.59E-02 -7.92E-02
Bladder cancer 2C94 Bladder tissue 3.12E-04 -5.74E-01 -2.32E+00
Breast cancer 2C60-2C6Z Breast tissue 7.88E-32 5.00E-01 8.69E-01
Cardioembolic stroke 8B11.20 Whole blood 9.54E-02 -9.05E-02 -7.39E-01
Cervical cancer 2C77 Cervical tissue 1.87E-01 -2.33E-01 -6.37E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 6.49E-01 5.77E-02 5.69E-02
Chronic hepatitis C 1E51.1 Whole blood 3.02E-01 -1.40E-01 -6.40E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 2.73E-01 2.81E-02 3.35E-02
Chronic obstructive pulmonary disease CA22 Small airway epithelium 1.78E-06 -5.20E-01 -9.78E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 1.63E-02 -1.12E+00 -1.47E+00
Colon cancer 2B90 Colon tissue 7.21E-02 1.17E-01 2.10E-01
Coronary artery disease BA80-BA8Z Peripheral blood 7.33E-02 2.96E-01 1.28E+00
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 6.25E-01 6.95E-02 2.20E-01
Endometriosis GA10 Endometrium tissue 9.34E-03 -3.12E-01 -8.02E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 3.33E-02 -1.25E-01 -7.81E-01
Familial hypercholesterolemia 5C80.00 Whole blood 2.23E-05 7.77E-01 1.55E+00
Gastric cancer 2B72 Gastric tissue 5.44E-01 -1.99E-03 -4.86E-03
Glioblastopma 2A00.00 Nervous tissue 3.09E-07 1.59E-01 2.50E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 9.60E-01 -5.18E-02 -8.42E-02
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.08E-03 4.40E-01 1.54E+00
Head and neck cancer 2D42 Head and neck tissue 2.27E-04 1.91E-01 4.28E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 3.97E-01 1.61E-01 3.85E-01
Huntington's disease 8A01.10 Whole blood 5.90E-01 -8.70E-02 -2.22E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 2.72E-02 -8.78E-01 -1.38E+00
Immunodeficiency 4A00-4A20 Peripheral blood 2.93E-01 7.36E-04 4.78E-03
Influenza 1E30 Whole blood 3.39E-02 -7.49E-01 -2.58E+00
Interstitial cystitis GC00.3 Bladder tissue 2.23E-02 -1.40E-01 -1.18E+00
Intracranial aneurysm 8B01.0 Intracranial artery 1.02E-01 -3.37E-01 -3.94E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 4.19E-01 -2.68E-04 -7.71E-04
Ischemic stroke 8B11 Peripheral blood 2.84E-02 -2.87E-01 -6.51E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 1.16E-01 -1.06E-01 -3.99E-01
Lateral sclerosis 8B60.4 Skin 1.56E-01 2.30E-01 9.25E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 5.35E-01 5.16E-02 2.01E-01
Liver cancer 2C12.0 Liver tissue 9.74E-01 -2.59E-02 -4.03E-02
Liver failure DB99.7-DB99.8 Liver tissue 2.34E-03 -4.93E-01 -1.27E+00
Lung cancer 2C25 Lung tissue 5.80E-01 -3.51E-02 -5.55E-02
Lupus erythematosus 4A40 Whole blood 3.49E-05 7.22E-01 1.08E+00
Major depressive disorder 6A70-6A7Z Hippocampus 1.33E-01 -8.58E-02 -4.45E-01
Major depressive disorder 6A70-6A7Z Whole blood 5.84E-01 -2.41E-02 -1.19E-01
Melanoma 2C30 Skin 3.02E-01 3.31E-01 5.07E-01
Multiple myeloma 2A83.1 Peripheral blood 6.85E-01 -2.33E-01 -4.29E-01
Multiple myeloma 2A83.1 Bone marrow 7.59E-05 5.46E-01 2.49E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.36E-01 1.35E-01 7.13E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 7.61E-01 -6.19E-02 -1.25E-01
Myelofibrosis 2A20.2 Whole blood 1.31E-01 -1.32E-01 -1.17E+00
Myocardial infarction BA41-BA50 Peripheral blood 1.97E-03 -3.06E-01 -7.78E-01
Myopathy 8C70.6 Muscle tissue 7.02E-01 -2.03E-01 -2.38E-01
Neonatal sepsis KA60 Whole blood 3.63E-02 2.03E-01 6.15E-01
Neuroectodermal tumour 2A00.11 Brain stem tissue 1.18E-02 -2.36E-01 -6.14E-01
Non-alcoholic fatty liver disease DB92 Liver tissue 6.20E-01 -1.28E-01 -2.90E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 7.10E-01 -5.67E-02 -1.04E-01
Olive pollen allergy CA08.00 Peripheral blood 3.99E-01 -1.35E-01 -6.38E-01
Oral cancer 2B6E Oral tissue 3.89E-01 2.64E-01 4.99E-01
Osteoarthritis FA00-FA0Z Synovial tissue 3.53E-01 1.88E-01 1.73E-01
Osteoporosis FB83.1 Bone marrow 8.34E-01 1.21E-01 3.53E-01
Ovarian cancer 2C73 Ovarian tissue 4.23E-01 3.72E-01 3.26E-01
Pancreatic cancer 2C10 Pancreas 5.12E-01 6.04E-02 9.06E-02
Parkinson's disease 8A00.0 Substantia nigra tissue 9.02E-01 1.12E-02 4.15E-02
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.64E-01 -5.94E-03 -2.43E-02
Pituitary cancer 2D12 Pituitary tissue 7.07E-01 7.59E-02 1.13E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 6.33E-01 2.77E-01 3.82E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 7.53E-01 -7.54E-02 -2.38E-01
Polycythemia vera 2A20.4 Whole blood 9.94E-14 -2.08E-01 -1.63E+00
Pompe disease 5C51.3 Biceps muscle 2.90E-01 4.48E-02 1.92E-01
Preterm birth KA21.4Z Myometrium 9.09E-01 -1.13E-01 -2.64E-01
Prostate cancer 2C82 Prostate 8.92E-01 -1.46E-01 -2.18E-01
Psoriasis EA90 Skin 1.45E-01 -1.75E-01 -3.78E-01
Rectal cancer 2B92 Rectal colon tissue 7.79E-04 8.42E-01 3.19E+00
Renal cancer 2C90-2C91 Kidney 9.54E-02 5.11E-01 9.45E-01
Retinoblastoma 2D02.2 Uvea 1.06E-03 9.88E-01 2.93E+00
Rheumatoid arthritis FA20 Synovial tissue 8.16E-08 1.46E+00 5.50E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 2.03E-01 1.28E-01 3.97E-01
Schizophrenia 6A20 Prefrontal cortex 8.80E-01 2.99E-03 1.03E-02
Schizophrenia 6A20 Superior temporal cortex 8.75E-01 3.33E-02 1.37E-01
Scleroderma 4A42.Z Whole blood 1.55E-02 -1.80E-01 -1.25E+00
Seizure 8A60-8A6Z Whole blood 7.83E-01 1.54E-01 6.25E-01
Sensitive skin EK0Z Skin 2.90E-01 1.70E-01 1.03E+00
Sepsis with septic shock 1G41 Whole blood 3.20E-06 -2.47E-02 -7.94E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 9.59E-01 -1.32E-01 -2.61E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.85E-01 -3.35E-03 -1.59E-02
Simpson golabi behmel syndrome LD2C Adipose tissue 4.23E-01 -4.76E-01 -1.22E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.79E-01 -1.18E-01 -4.53E-01
Skin cancer 2C30-2C3Z Skin 5.57E-04 1.21E-01 2.17E-01
Thrombocythemia 3B63 Whole blood 4.60E-05 -2.34E-01 -2.08E+00
Thrombocytopenia 3B64 Whole blood 3.63E-01 -8.20E-02 -2.57E-01
Thyroid cancer 2D10 Thyroid 1.69E-17 -5.59E-01 -1.17E+00
Tibial muscular dystrophy 8C75 Muscle tissue 3.81E-01 -9.39E-02 -2.03E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 1.78E-01 -4.52E-01 -8.37E-01
Type 2 diabetes 5A11 Liver tissue 9.58E-01 3.95E-02 2.31E-01
Ureter cancer 2C92 Urothelium 7.83E-01 7.91E-02 1.86E-01
Uterine cancer 2C78 Endometrium tissue 2.32E-02 -2.84E-01 -5.06E-01
Vitiligo ED63.0 Skin 3.90E-01 1.65E-01 1.06E+00
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name S-adenosylmethionine synthase type-2 (MAT2A) DTT Info
DME DTT Type Clinical trial
1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
AG-270 DMYTJG7 Lymphoma 2A80-2A86 Phase 1 [1]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18.