Details of the Drug-Related molecule(s) Expression Atlas

General Information of DME (ID: DE76G8C)

• DME Name: S-adenosylmethionine synthase 2 (MAT2A) DME Info
• Gene Name: MAT2A

The Expression Level of Molecule(s) in Normal Tissue

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Acute myelocytic leukaemia	2B33.1	Bone marrow	1.49E-01	9.01E-02	1.47E-01
Alopecia	ED70	Skin from scalp	5.70E-01	-2.57E-02	-1.08E-01
Alzheimer's disease	8A20	Entorhinal cortex	5.54E-04	1.30E-01	4.15E-01
Ankylosing spondylitis	FA92.0	Pheripheral blood	2.33E-01	3.22E-01	8.25E-01
Aortic stenosis	BB70	Calcified aortic valve	4.60E-01	-2.56E-01	-4.02E-01
Apnea	7A40	Hyperplastic tonsil	8.53E-02	-3.09E-01	-4.25E-01
Arthropathy	FA00-FA5Z	Peripheral blood	2.38E-03	-1.54E-01	-7.28E-01
Asthma	CA23	Nasal and bronchial airway	3.25E-02	1.93E-02	3.21E-02
Atopic dermatitis	EA80	Skin	2.84E-01	-6.57E-04	-1.34E-03
Autism	6A02	Whole blood	2.02E-01	-8.20E-02	-1.93E-01
Autoimmune uveitis	9A96	Peripheral monocyte	2.16E-01	1.64E-01	6.25E-01
Autosomal dominant monocytopenia	4B04	Whole blood	3.45E-01	-3.03E-01	-4.53E-01
Bacterial infection of gingival	1C1H	Gingival tissue	1.19E-01	1.46E-01	3.58E-01
Batten disease	5C56.1	Whole blood	4.58E-01	-1.71E-01	-1.12E+00
Behcet's disease	4A62	Peripheral blood	6.44E-01	-5.07E-02	-1.26E-01
Bipolar disorder	6A60-6A6Z	Prefrontal cortex	7.88E-01	-1.59E-02	-7.92E-02
Bladder cancer	2C94	Bladder tissue	3.12E-04	-5.74E-01	-2.32E+00
Breast cancer	2C60-2C6Z	Breast tissue	7.88E-32	5.00E-01	8.69E-01
Cardioembolic stroke	8B11.20	Whole blood	9.54E-02	-9.05E-02	-7.39E-01
Cervical cancer	2C77	Cervical tissue	1.87E-01	-2.33E-01	-6.37E-01
Childhood onset rheumatic disease	FA20.Z	Peripheral blood	6.49E-01	5.77E-02	5.69E-02
Chronic hepatitis C	1E51.1	Whole blood	3.02E-01	-1.40E-01	-6.40E-01
Chronic obstructive pulmonary disease	CA22	Lung tissue	2.73E-01	2.81E-02	3.35E-02
Chronic obstructive pulmonary disease	CA22	Small airway epithelium	1.78E-06	-5.20E-01	-9.78E-01
Chronic rhinosinusitis	CA0A	Sinus mucosa tissue	1.63E-02	-1.12E+00	-1.47E+00
Colon cancer	2B90	Colon tissue	7.21E-02	1.17E-01	2.10E-01
Coronary artery disease	BA80-BA8Z	Peripheral blood	7.33E-02	2.96E-01	1.28E+00
Diffuse large B-cell lymphoma	2A81	Tonsil tissue	6.25E-01	6.95E-02	2.20E-01
Endometriosis	GA10	Endometrium tissue	9.34E-03	-3.12E-01	-8.02E-01
Familial hypercholesterolemia	5C80.00	Peripheral blood	3.33E-02	-1.25E-01	-7.81E-01
Familial hypercholesterolemia	5C80.00	Whole blood	2.23E-05	7.77E-01	1.55E+00
Gastric cancer	2B72	Gastric tissue	5.44E-01	-1.99E-03	-4.86E-03
Glioblastopma	2A00.00	Nervous tissue	3.09E-07	1.59E-01	2.50E-01
Glioma	2A00.0Y-2A00.0Z	Brain stem tissue	9.60E-01	-5.18E-02	-8.42E-02
Glioma	2A00.0Y-2A00.0Z	White matter tissue	2.08E-03	4.40E-01	1.54E+00
Head and neck cancer	2D42	Head and neck tissue	2.27E-04	1.91E-01	4.28E-01
HIV-associated neurocognitive impairment	8A2Y-8A2Z	White matter tissue	3.97E-01	1.61E-01	3.85E-01
Huntington's disease	8A01.10	Whole blood	5.90E-01	-8.70E-02	-2.22E-01
Idiopathic pulmonary fibrosis	CB03.4	Lung tissue	2.72E-02	-8.78E-01	-1.38E+00
Immunodeficiency	4A00-4A20	Peripheral blood	2.93E-01	7.36E-04	4.78E-03
Influenza	1E30	Whole blood	3.39E-02	-7.49E-01	-2.58E+00
Interstitial cystitis	GC00.3	Bladder tissue	2.23E-02	-1.40E-01	-1.18E+00
Intracranial aneurysm	8B01.0	Intracranial artery	1.02E-01	-3.37E-01	-3.94E-01
Irritable bowel syndrome	DD91.0	Rectal colon tissue	4.19E-01	-2.68E-04	-7.71E-04
Ischemic stroke	8B11	Peripheral blood	2.84E-02	-2.87E-01	-6.51E-01
Juvenile idiopathic arthritis	FA24	Peripheral blood	1.16E-01	-1.06E-01	-3.99E-01
Lateral sclerosis	8B60.4	Skin	1.56E-01	2.30E-01	9.25E-01
Lateral sclerosis	8B60.4	Cervical spinal cord	5.35E-01	5.16E-02	2.01E-01
Liver cancer	2C12.0	Liver tissue	9.74E-01	-2.59E-02	-4.03E-02
Liver failure	DB99.7-DB99.8	Liver tissue	2.34E-03	-4.93E-01	-1.27E+00
Lung cancer	2C25	Lung tissue	5.80E-01	-3.51E-02	-5.55E-02
Lupus erythematosus	4A40	Whole blood	3.49E-05	7.22E-01	1.08E+00
Major depressive disorder	6A70-6A7Z	Hippocampus	1.33E-01	-8.58E-02	-4.45E-01
Major depressive disorder	6A70-6A7Z	Whole blood	5.84E-01	-2.41E-02	-1.19E-01
Melanoma	2C30	Skin	3.02E-01	3.31E-01	5.07E-01
Multiple myeloma	2A83.1	Peripheral blood	6.85E-01	-2.33E-01	-4.29E-01
Multiple myeloma	2A83.1	Bone marrow	7.59E-05	5.46E-01	2.49E+00
Multiple sclerosis	8A40	Plasmacytoid dendritic cells	3.36E-01	1.35E-01	7.13E-01
Myelodysplastic syndrome	2A36-2A3Z	Bone marrow	7.61E-01	-6.19E-02	-1.25E-01
Myelofibrosis	2A20.2	Whole blood	1.31E-01	-1.32E-01	-1.17E+00
Myocardial infarction	BA41-BA50	Peripheral blood	1.97E-03	-3.06E-01	-7.78E-01
Myopathy	8C70.6	Muscle tissue	7.02E-01	-2.03E-01	-2.38E-01
Neonatal sepsis	KA60	Whole blood	3.63E-02	2.03E-01	6.15E-01
Neuroectodermal tumour	2A00.11	Brain stem tissue	1.18E-02	-2.36E-01	-6.14E-01
Non-alcoholic fatty liver disease	DB92	Liver tissue	6.20E-01	-1.28E-01	-2.90E-01
Obesity related type 2 diabetes	5A11	Omental adipose tissue	7.10E-01	-5.67E-02	-1.04E-01
Olive pollen allergy	CA08.00	Peripheral blood	3.99E-01	-1.35E-01	-6.38E-01
Oral cancer	2B6E	Oral tissue	3.89E-01	2.64E-01	4.99E-01
Osteoarthritis	FA00-FA0Z	Synovial tissue	3.53E-01	1.88E-01	1.73E-01
Osteoporosis	FB83.1	Bone marrow	8.34E-01	1.21E-01	3.53E-01
Ovarian cancer	2C73	Ovarian tissue	4.23E-01	3.72E-01	3.26E-01
Pancreatic cancer	2C10	Pancreas	5.12E-01	6.04E-02	9.06E-02
Parkinson's disease	8A00.0	Substantia nigra tissue	9.02E-01	1.12E-02	4.15E-02
Pediatric respiratory syncytial virus infection	CA40.11	Peripheral blood	9.64E-01	-5.94E-03	-2.43E-02
Pituitary cancer	2D12	Pituitary tissue	7.07E-01	7.59E-02	1.13E-01
Pituitary gonadotrope tumour	2D12	Pituitary tissue	6.33E-01	2.77E-01	3.82E-01
Polycystic ovary syndrome	5A80.1	Vastus lateralis muscle	7.53E-01	-7.54E-02	-2.38E-01
Polycythemia vera	2A20.4	Whole blood	9.94E-14	-2.08E-01	-1.63E+00
Pompe disease	5C51.3	Biceps muscle	2.90E-01	4.48E-02	1.92E-01
Preterm birth	KA21.4Z	Myometrium	9.09E-01	-1.13E-01	-2.64E-01
Prostate cancer	2C82	Prostate	8.92E-01	-1.46E-01	-2.18E-01
Psoriasis	EA90	Skin	1.45E-01	-1.75E-01	-3.78E-01
Rectal cancer	2B92	Rectal colon tissue	7.79E-04	8.42E-01	3.19E+00
Renal cancer	2C90-2C91	Kidney	9.54E-02	5.11E-01	9.45E-01
Retinoblastoma	2D02.2	Uvea	1.06E-03	9.88E-01	2.93E+00
Rheumatoid arthritis	FA20	Synovial tissue	8.16E-08	1.46E+00	5.50E+00
Rhinovirus infection	CA42.1	Nasal epithelium tissue	2.03E-01	1.28E-01	3.97E-01
Schizophrenia	6A20	Prefrontal cortex	8.80E-01	2.99E-03	1.03E-02
Schizophrenia	6A20	Superior temporal cortex	8.75E-01	3.33E-02	1.37E-01
Scleroderma	4A42.Z	Whole blood	1.55E-02	-1.80E-01	-1.25E+00
Seizure	8A60-8A6Z	Whole blood	7.83E-01	1.54E-01	6.25E-01
Sensitive skin	EK0Z	Skin	2.90E-01	1.70E-01	1.03E+00
Sepsis with septic shock	1G41	Whole blood	3.20E-06	-2.47E-02	-7.94E-02
Shwachman-Diamond syndrome	3A70.0	Bone marrow	9.59E-01	-1.32E-01	-2.61E-01
Sickle cell disease	3A51.0-3A51.3	Peripheral blood	1.85E-01	-3.35E-03	-1.59E-02
Simpson golabi behmel syndrome	LD2C	Adipose tissue	4.23E-01	-4.76E-01	-1.22E+00
Sjogren's syndrome	4A43.2	Salivary gland tissue	3.79E-01	-1.18E-01	-4.53E-01
Skin cancer	2C30-2C3Z	Skin	5.57E-04	1.21E-01	2.17E-01
Thrombocythemia	3B63	Whole blood	4.60E-05	-2.34E-01	-2.08E+00
Thrombocytopenia	3B64	Whole blood	3.63E-01	-8.20E-02	-2.57E-01
Thyroid cancer	2D10	Thyroid	1.69E-17	-5.59E-01	-1.17E+00
Tibial muscular dystrophy	8C75	Muscle tissue	3.81E-01	-9.39E-02	-2.03E-01
Tuberous sclerosis complex	LD2D.2	Perituberal tissue	1.78E-01	-4.52E-01	-8.37E-01
Type 2 diabetes	5A11	Liver tissue	9.58E-01	3.95E-02	2.31E-01
Ureter cancer	2C92	Urothelium	7.83E-01	7.91E-02	1.86E-01
Uterine cancer	2C78	Endometrium tissue	2.32E-02	-2.84E-01	-5.06E-01
Vitiligo	ED63.0	Skin	3.90E-01	1.65E-01	1.06E+00