Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE82GV7)

DME Name	NADPH-dependent oxidoreductase (nfrA)
Synonyms	NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1; SAOUHSC_00366; nfrA
Gene Name	nfrA
UniProt ID	NRFA_STAA8
INTEDE ID	DME1242
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	3919785
EC Number	EC: 1.6.5.2 Oxidoreductase NADH/NADPH oxidoreductase Quinone acceptor oxidoreductase EC: 1.6.5.2
Lineage	Species: Staphylococcus aureus Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Staphylococcaceae Genus: Staphylococcus Species: Staphylococcus aureus
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKEN LREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAEN IAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPF DHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDML EQLQKSGLIQR
Function	This enzyme reduces FMN, organic nitro compounds and disulfide DTNB. And it is involved in maintenance of the cellular redox state and the disulfide stress response.
KEGG Pathway	Metabolic pathways (sao01100 ) Riboflavin metabolism (sao00740 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

3 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1], [2]
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[1], [2]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[1]
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References

1	Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500.
2	The human gut microbiota: metabolism and perspective in obesity. Gut Microbes. 2018 Jul 4;9(4):308-325.