Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE84PFW)

DME Name	Cardiac glycoside reductase 1 (cgr1)
Synonyms	Cardiac glycoside reductase operon protein 1; Cytochrome c-type protein Cgr1; cgr1
Gene Name	cgr1
UniProt ID	CGR1_EGGLE
INTEDE ID	DME1035
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Gene ID	40923313
EC Number	EC: 1.3.2.- Oxidoreductase CH-CH donor oxidoreductase Quinone acceptor oxidoreductase EC: 1.3.2.-
Lineage	Species: Eggerthella lenta Kingdom: Bacteria Phylum: Actinobacteria Class: Coriobacteriia Order: Eggerthellales Family: Eggerthellaceae Genus: Eggerthella Species: Eggerthella lenta
Tissue Distribution	Primarily distributed in human gut.
Sequence	MAEEPVVIGDPAPRTRKWPIVVGVVVVVLIAAGAGFWVWHEQPSFCAAICHTPMDEYLET YEQEAGTAGVDKWGNEVANTNAMLAVSHKAQGKDCMACHVPTLSEQMSEGMNWVTGNYVY PLEERDTEMLTEARGVDADEFCLNESCHNLTRDDLIKATSDMEFNPHQPQHGEIECSECH KAHRASVMYCTQCHSEAEVPEGWLTVAEANKLSTAA
Function	This enzyme anchors as a dimer in the cytoplasmic membrane and shuttles quinone derived electrons to associated periplasmic nitrite reductases.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[1]
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References

1	Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8.