Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE86CHA)

DME Name Xylose isomerase (xylA)
Synonyms Xylose isomerase xylA; Isomerase xylA; Enzyme xylA; xylA; BAD_0422
Gene Name xylA
UniProt ID
XYLA_BIFAA
INTEDE ID
DME1164
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
4556760
EC Number EC: 5.3.1.5
Isomerase
Intramolecular oxidoreductase
Aldose/ketose isomerase
EC: 5.3.1.5
Lineage Species: Bifidobacterium adolescentis
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium adolescentis
Tissue Distribution Primarily distributed in human gut.
Sequence
MGLWDIDKIPYVGREKGPQEGLAFHYYDADKVVAGKKMKDWLRFGVAWWHTFDQQLVDPF
GTGTAQRPWYGKYSDPEDEALAKVDYAFEFFQKLGVEYFCFHDRDIAPEGDTLRETDKNL
DKVVDKIEENMKSTGIKLLWNTSSLFTNPRFVSGASTSPFADIYAYAGGQLKHSLEIAKR
LGAENYVFWGGREGYENLWNTQMKREQEHMAKFFHMCHDYAKEIGLDAQFLIEPKAKEPT
MFQYDFDAATAINFLRTYDLMDVFKLNLEGNHANLAGHTYQHEIRTAREAGVLGSLDANQ
GDKLIGWDMDEFPTDLYETSTVMWEVLAEGQIGPHGGLNFDAKPRRTSFTAEDLFRSHIA
GMDSFAAGLLVAAKMHEDKVIENLQAERYSSFDSGIGATVENGTASLASLEEYALDIPQS
KLIEATKSDHLESVKATINNYMIDALAEA
Function
This enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. It binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
KEGG Pathway
Fructose and mannose metabolism (bad00051 )
Metabolic pathways (bad01100 )
Pentose and glucuronate interconversions (bad00040 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Xylose DMAR467 Gastrointestinal disease DE2Z Approved [1]
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
Xylose Gastrointestinal disease [DE2Z] Approved Km = 4000 microM [1]

References

1 Purification and characterization of D-xylose isomerase from Bifidobacterium adolescentis. Biosci Biotechnol Biochem. 1994 Apr;58(4):691-4.