Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE8BVKA)

DME Name Indoleamine 2,3-dioxygenase 2 (IDO2)
Synonyms Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; IDO-2; IDO2; INDOL1
Gene Name IDO2
UniProt ID
I23O2_HUMAN
INTEDE ID
DME0459
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
169355
EC Number EC: 1.13.11.52
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.52
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIA
NKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVL
PRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGF
ILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDP
DIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSK
ESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYH
ITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
Function This enzyme catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway.
KEGG Pathway
African trypanosomiasis (hsa05143 )
Metabolic pathways (hsa01100 )
Tryptophan metabolism (hsa00380 )
Reactome Pathway
Tryptophan catabolism (R-HSA-71240 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [2]
Experimental Enzyme Kinetic Data of Drugs
Drug Name Indication Highest Status Kinetic Data REF
L-Tryptophan Depression [6A70-6A7Z] Approved Km = 0.02 microM [2]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 8.67E-02 -3.02E-02 -1.87E-01
Alopecia ED70 Skin from scalp 3.89E-06 4.46E-01 9.48E-01
Alzheimer's disease 8A20 Entorhinal cortex 4.98E-01 1.05E-02 6.18E-02
Ankylosing spondylitis FA92.0 Pheripheral blood 1.51E-01 -1.38E-01 -5.85E-01
Aortic stenosis BB70 Calcified aortic valve 7.75E-01 -2.35E-02 -4.73E-02
Apnea 7A40 Hyperplastic tonsil 6.32E-01 9.44E-02 3.20E-01
Arthropathy FA00-FA5Z Peripheral blood 4.46E-01 4.22E-04 2.46E-03
Asthma CA23 Nasal and bronchial airway 3.47E-03 1.63E-01 3.14E-01
Atopic dermatitis EA80 Skin 2.12E-01 8.37E-02 3.43E-01
Autism 6A02 Whole blood 4.92E-01 -1.17E-02 -5.68E-02
Autoimmune uveitis 9A96 Peripheral monocyte 8.46E-02 -1.67E-01 -1.04E+00
Autosomal dominant monocytopenia 4B04 Whole blood 8.65E-02 -8.31E-02 -3.88E-01
Bacterial infection of gingival 1C1H Gingival tissue 9.09E-01 1.79E-02 5.20E-02
Batten disease 5C56.1 Whole blood 1.45E-01 -5.20E-02 -3.30E-01
Behcet's disease 4A62 Peripheral blood 9.12E-01 -1.19E-01 -5.51E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 9.54E-01 1.93E-02 1.26E-01
Bladder cancer 2C94 Bladder tissue 2.01E-04 7.55E-01 2.67E+00
Breast cancer 2C60-2C6Z Breast tissue 7.30E-07 6.23E-02 2.42E-01
Cardioembolic stroke 8B11.20 Whole blood 2.65E-01 -2.40E-01 -4.58E-01
Cervical cancer 2C77 Cervical tissue 2.75E-01 3.23E-02 1.42E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.79E-01 -4.94E-02 -1.81E-01
Chronic hepatitis C 1E51.1 Whole blood 8.26E-01 -4.54E-02 -2.93E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 9.35E-02 8.45E-02 4.77E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 7.61E-02 3.00E-02 2.18E-01
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.54E-01 4.64E-02 3.07E-01
Colon cancer 2B90 Colon tissue 8.80E-01 -2.26E-02 -8.44E-02
Coronary artery disease BA80-BA8Z Peripheral blood 8.44E-01 -6.48E-02 -4.39E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 7.95E-01 -6.10E-02 -3.43E-01
Endometriosis GA10 Endometrium tissue 6.18E-02 1.54E-01 1.15E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 7.66E-01 -1.75E-02 -1.07E-01
Familial hypercholesterolemia 5C80.00 Whole blood 8.98E-01 -3.27E-02 -1.94E-01
Gastric cancer 2B72 Gastric tissue 9.61E-01 -1.02E-01 -3.64E-01
Glioblastopma 2A00.00 Nervous tissue 1.82E-01 -1.54E-02 -4.04E-02
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 5.13E-01 -1.37E+00 -6.80E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 2.83E-02 6.15E-02 3.13E-01
Head and neck cancer 2D42 Head and neck tissue 9.35E-03 8.09E-02 3.36E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 4.21E-02 -7.38E-02 -2.85E-01
Huntington's disease 8A01.10 Whole blood 8.93E-01 5.56E-02 1.93E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 3.46E-01 4.87E-02 2.39E-01
Immunodeficiency 4A00-4A20 Peripheral blood 5.60E-01 -9.37E-02 -1.16E+00
Influenza 1E30 Whole blood 3.55E-02 1.27E+00 2.23E+00
Interstitial cystitis GC00.3 Bladder tissue 1.54E-01 1.43E-01 6.86E-01
Intracranial aneurysm 8B01.0 Intracranial artery 9.00E-02 1.75E-01 7.64E-01
Irritable bowel syndrome DD91.0 Rectal colon tissue 7.52E-01 3.52E-04 8.35E-04
Ischemic stroke 8B11 Peripheral blood 8.53E-01 8.43E-03 5.35E-02
Juvenile idiopathic arthritis FA24 Peripheral blood 5.59E-02 -1.29E-01 -3.17E-01
Lateral sclerosis 8B60.4 Skin 7.05E-01 4.11E-02 4.15E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 3.61E-01 -5.77E-02 -3.65E-01
Liver cancer 2C12.0 Liver tissue 2.24E-09 -2.43E+00 -1.60E+00
Liver failure DB99.7-DB99.8 Liver tissue 6.63E-01 3.08E-02 6.92E-02
Lung cancer 2C25 Lung tissue 1.08E-11 1.01E-01 4.11E-01
Lupus erythematosus 4A40 Whole blood 9.72E-01 -1.91E-02 -6.37E-02
Major depressive disorder 6A70-6A7Z Hippocampus 7.75E-01 -1.11E-02 -7.41E-02
Major depressive disorder 6A70-6A7Z Whole blood 9.21E-02 -6.35E-02 -1.86E-01
Melanoma 2C30 Skin 3.31E-01 5.07E-02 8.67E-02
Multiple myeloma 2A83.1 Peripheral blood 6.15E-01 5.66E-02 4.27E-01
Multiple myeloma 2A83.1 Bone marrow 1.97E-05 -6.02E-01 -3.80E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 3.50E-01 -7.76E-02 -3.18E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 2.98E-02 1.09E-01 7.09E-01
Myelofibrosis 2A20.2 Whole blood 3.70E-01 5.02E-02 4.64E-01
Myocardial infarction BA41-BA50 Peripheral blood 3.74E-01 1.07E-01 2.18E-01
Myopathy 8C70.6 Muscle tissue 9.97E-01 -9.33E-03 -4.08E-02
Neonatal sepsis KA60 Whole blood 2.79E-01 1.02E-02 5.54E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.93E-03 -8.78E-01 -1.46E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 9.24E-01 -8.03E-02 -7.83E-02
Obesity related type 2 diabetes 5A11 Omental adipose tissue 1.18E-01 1.53E-01 1.56E+00
Olive pollen allergy CA08.00 Peripheral blood 9.80E-01 2.92E-01 4.43E-01
Oral cancer 2B6E Oral tissue 3.65E-01 -1.25E-01 -2.94E-01
Osteoarthritis FA00-FA0Z Synovial tissue 3.20E-01 2.19E-02 6.42E-02
Osteoporosis FB83.1 Bone marrow 1.33E-01 -1.37E-01 -3.41E+00
Ovarian cancer 2C73 Ovarian tissue 2.64E-02 1.00E-01 4.15E-01
Pancreatic cancer 2C10 Pancreas 3.38E-01 -8.82E-02 -1.66E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 5.53E-01 2.17E-02 1.02E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 9.28E-01 1.45E-02 1.15E-01
Pituitary cancer 2D12 Pituitary tissue 5.13E-01 -1.49E-01 -6.55E-01
Pituitary gonadotrope tumour 2D12 Pituitary tissue 9.47E-02 -1.53E-01 -4.99E-01
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 9.04E-01 7.15E-03 5.31E-02
Polycythemia vera 2A20.4 Whole blood 1.19E-04 5.35E-02 3.86E-01
Pompe disease 5C51.3 Biceps muscle 9.41E-01 -3.18E-02 -3.70E-01
Preterm birth KA21.4Z Myometrium 3.93E-01 -1.13E-02 -5.99E-02
Prostate cancer 2C82 Prostate 4.69E-02 -2.29E-01 -4.34E-01
Psoriasis EA90 Skin 5.11E-12 1.93E-01 7.16E-01
Rectal cancer 2B92 Rectal colon tissue 3.49E-01 4.10E-02 1.93E-01
Renal cancer 2C90-2C91 Kidney 5.89E-03 -4.86E-01 -1.30E+00
Retinoblastoma 2D02.2 Uvea 2.52E-03 -3.09E-01 -2.96E+00
Rheumatoid arthritis FA20 Synovial tissue 8.03E-02 -4.35E-01 -8.64E-01
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.04E-01 1.41E-02 7.93E-02
Schizophrenia 6A20 Prefrontal cortex 1.54E-01 4.04E-02 1.13E-01
Schizophrenia 6A20 Superior temporal cortex 6.28E-01 0.00E+00 0.00E+00
Scleroderma 4A42.Z Whole blood 9.41E-03 -2.26E-01 -1.49E+00
Seizure 8A60-8A6Z Whole blood 3.32E-01 1.59E-01 7.02E-01
Sensitive skin EK0Z Skin 5.53E-01 8.88E-03 5.94E-02
Sepsis with septic shock 1G41 Whole blood 3.86E-01 2.84E-03 1.37E-02
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.29E-01 1.93E-01 6.48E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 1.66E-02 5.40E-02 4.82E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 7.62E-03 1.68E-01 4.63E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 3.20E-02 1.11E-01 4.45E+00
Skin cancer 2C30-2C3Z Skin 1.17E-01 7.11E-02 2.07E-01
Thrombocythemia 3B63 Whole blood 6.59E-01 3.09E-03 2.81E-02
Thrombocytopenia 3B64 Whole blood 6.87E-01 -1.02E-01 -4.34E-01
Thyroid cancer 2D10 Thyroid 1.19E-07 -3.12E-01 -7.88E-01
Tibial muscular dystrophy 8C75 Muscle tissue 8.31E-01 3.88E-03 2.24E-02
Tuberous sclerosis complex LD2D.2 Perituberal tissue 6.69E-01 -1.19E-02 -8.55E-02
Type 2 diabetes 5A11 Liver tissue 4.29E-01 -4.52E-02 -9.13E-02
Ureter cancer 2C92 Urothelium 1.91E-01 5.09E-02 3.08E-01
Uterine cancer 2C78 Endometrium tissue 1.47E-03 -8.65E-04 -4.92E-04
Vitiligo ED63.0 Skin 7.33E-01 -2.77E-01 -7.04E-01
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⏷ Show the Full List of DME Expression Under 107 Diseases

The Drug Therapeutic Target (DTT) Role of This DME

DME DTT Name Indoleamine 2,3-dioxygenase 2 (IDO2) DTT Info
DME DTT Type Patented-recorded
8 Patented Agent(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2,3-diamino-benzo[b]thiophene derivative 1 DMD2KRW N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 2 DMDYXKT N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 4 DMEDFNC N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 5 DM05WXD N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 6 DMINE6V N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 7 DMQVMNJ N. A. N. A. Patented [1]
2,3-diamino-benzo[b]thiophene derivative 8 DM5O8K0 N. A. N. A. Patented [1]
PMID27172114-Compound-30 DMBWLSA N. A. N. A. Patented [1]
⏷ Show the Full List of 8 Patented Agent(s)

References

1 Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.
2 Kynurenine pathway metabolites and enzymes involved in redox reactions. Neuropharmacology. 2017 Jan;112(Pt B):331-345.