Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE9N4OU)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Amir_1683
• Gene Name: bglA
• UniProt ID: C6WCL5_ACTMD
• INTEDE ID: DME1204
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Actinosynnema mirum
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Pseudonocardiales
  Family: Pseudonocardiaceae
  Genus: Actinosynnema
  Species: Actinosynnema mirum
  Subspecies: Actinosynnema mirum KACC 20028
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MDTTARAAGFDPAIASLPPSFRWGVATSAYQIEGAVAEDGRGPSIWDTYCRVPGMVHEGD
  NGDVACDHYHRMPEDVELIRSLGVDTYRFSVAWPRVQPGGTGPANPKGLAFYDRLVDELL
  AKGVDPWVTLYHWDLPQELEDAGGWPVRDTAHRFADYSMLVFDALQDRVRTWTTLNEPWC
  SAMLGYHVGRQAPGRTHFPDAIKAVHHLLLGHGLATRRMREAAVKPTEFGITLNMGHAAP
  ATDSELDRDAARRADGLGRRIYLHPVVTGEYPADVVADLAARGAELPVRDGDLELISQPI
  EVLGINHYTSSKHSGTAEDGSTVDADGLPVDRELRYGRPVTAMDWEIVPEQFTELLLQNA
  REYPDLPPMVITENGAAFDDVVSPDGSVDDADRVAYLDSHIAAVAKAREGGADVRGYFAW
  SLMDNFEWSYGYEKRFGIVHVDYETQVRTPKASALWYRDVAKRVRES
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (ami01110)
  Cyanoamino acid metabolism (ami00460)
  Metabolic pathways (ami01100)
  Starch and sucrose metabolism (ami00500)

Molecular Interaction Atlas (MIA) of This DME

1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SC-46553	DM6XNJR	N. A.	N. A.	Phase 3	[1]

3 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]
Ginsenoside Re	DM46FVD	N. A.	N. A.	Investigative	[1]
Ginsenoside Rg1	DMYE2SR	N. A.	N. A.	Investigative	[1]

References

• [1] Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59.