General Information of Drug-Metabolizing Enzyme (DME) (ID: DEASJG5)

DME Name Beta-glucosidase (bglA)
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; RUMOBE_00331
Gene Name bglA
UniProt ID
A5ZMW4_9FIRM
INTEDE ID
DME1967
Gene ID
42450648
EC Number EC: 3.2.1.21
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage Species: Blautia obeum
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
Tissue Distribution Primarily distributed in human gut.
Sequence
MPTENYKFPADFVWGAATSSYQIEGAVSEDGKGEDIWDVFTKEDHRIFEHHTGETACDHY
HRFKEDVKLMKEIGLHAYRFSINWSRVLPNGYGQVNEKGIAFYNALINELLANDIEPYIT
LYHWELPYELYKRGGWLNPQIVDWFGDYARLIAERFSDRVKNFFILNEPQCFVGLGFLTG
EHAPGVQAPLRDTFEMAHNALKAHGKAVQMLRAYGKQKLSIGFAPTASMCYPETESAEDI
EAARKALFSLPDDPHNWTWNVSWWSDPVFFGKYPEEGLQKYEKYLPKITDDDMKLISEPI
DIYGQNIYNGQCIRMGKDGHPEYVRRYEGFPKTAIDWPVTPECLNWGPRFLYERYKTPIY
ITENGMSCHDVVSLDGKVHDPNRIDFLARYLDELKKAATVADIRGYFQWSLMDNFEWSKG
YSERFGLIYIDYQTQQRILKDSAYWYKDYIKNNGEF
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ginsenoside Rb1 DMF70AB N. A. N. A. Investigative [1]

References

1 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.