General Information of Drug-Metabolizing Enzyme (DME) (ID: DEAZSKX)

DME Name Beta-glucosidase (bglA)
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BG; H109_07780
Gene Name bglA
UniProt ID
A0A059IXB8_TRIIM
INTEDE ID
DME1045
EC Number EC: 3.2.1.21
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage Species: Trichophyton interdigitale
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Species: Trichophyton interdigitale

Subspecies: Trichophyton interdigitale NCPF 0335
Tissue Distribution Primarily distributed in human skin.
Sequence
MLFRWCPLVALAIASGTAATEQSWESPPYYPSPWTKGEGEWEDAYQKAVSFVSQLTLAEK
VNLTTGVGWMQESCVGQVGSIPRLGFRSLCMQDGPLGIRFGDYVTAFPAGINVAATWSRE
LAYLRGKAMGEEFHGKGADVILGPAIGPIGRAPEGGRNWEGFGPDPVLAGRLVAETIKGM
QKTGVIACAKHFIANEQERFRIAAEAQGYGFDIAESISSNVDDVTMHEIYLWPFADAVKA
GVGSIMCSYNQINNSYGCGNSYTQNKLLKGELGFRGFIMSDWQAHHSGVGSAFAGLDMSM
PGDTLFGTGVSFWGANLTIAVANGTIPEWRVDDMAVRIMAAYYKVGRDKVQVPINFNSWT
TDVEGYQHALVKEGYGVVNQRVNVRDHHARIARRMASDSIVLLKNEGVLPLTGTEQFTAI
IGEDAGPNINGPNSCPDRGCDNGTLAMGWGSGTTNFPYLVTPDDAIQREIVAKGVGNVMS
VLQNGDFKNIQSVAGQANVALVFINSDSGEGYISVDGNEGDRKNLTTWKGGDEMVKQVTS
VCNNTVLVIHSSGPILAGQWHDNPNITAILWAGLPGQESGNALVDVLYGKVNPGGKSPFT
WGRTAEDYGTTILREPNNGKGAPQHQFSEGIMFEYRHFDQQNITPVYEFGYGLSYTTFSY
SNLRVRPMRANKYVPATGMTKPAPRLGHSSTKYADYLFPGGFKGVTKYVYPWLTSTDPKE
ASGDKNYGMPLEDYVPPNANNGDAQPVLPASGVPGGNPGLFEDLYKVSAVITNDGDRVGE
EVPQLYISLGGDRNAKVVLRGFDRIRLAPRQRFRWRTTITRRDISNWDPASQDWVMTEHP
KIVYVGSSSRNLPLQAPLPPPNLA
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
1 Investigative Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Esculin DMANEC9 N. A. N. A. Investigative [1]

References

1 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.