Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEB3TNR)

• DME Name: Tyramine oxidase (tynA)
• Synonyms: Copper amine oxidase; Primary amine oxidase; 2-phenylethylamine oxidase; JW1381; b1386; Bacterial maoA; tynA
• Gene Name: tynA
• UniProt ID: AMO_ECOLI
• INTEDE ID: DME1022
• Gene ID: 945939
• EC Number:
  EC: 1.4.3.21
  Oxidoreductase
  CH-NH2 donor oxidoreductase
  Oxygen acceptor oxidoreductase
  EC: 1.4.3.21
• Lineage:
  Species: Escherichia coli
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Escherichia
  Species: Escherichia coli
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MGSPSLYSARKTTLALAVALSFAWQAPVFAHGGEAHMVPMDKTLKEFGADVQWDDYAQLF
  TLIKDGAYVKVKPGAQTAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQSGLDQTFQVE
  KRPHPLNALTADEIKQAVEIVKASADFKPNTRFTEISLLPPDKEAVWAFALENKPVDQPR
  KADVIMLDGKHIIEAVVDLQNNKLLSWQPIKDAHGMVLLDDFASVQNIINNSEEFAAAVK
  KRGITDAKKVITTPLTVGYFDGKDGLKQDARLLKVISYLDVGDGNYWAHPIENLVAVVDL
  EQKKIVKIEEGPVVPVPMTARPFDGRDRVAPAVKPMQIIEPEGKNYTITGDMIHWRNWDF
  HLSMNSRVGPMISTVTYNDNGTKRKVMYEGSLGGMIVPYGDPDIGWYFKAYLDSGDYGMG
  TLTSPIARGKDAPSNAVLLNETIADYTGVPMEIPRAIAVFERYAGPEYKHQEMGQPNVST
  ERRELVVRWISTVGNYDYIFDWIFHENGTIGIDAGATGIEAVKGVKAKTMHDETAKDDTR
  YGTLIDHNIVGTTHQHIYNFRLDLDVDGENNSLVAMDPVVKPNTAGGPRTSTMQVNQYNI
  GNEQDAAQKFDPGTIRLLSNPNKENRMGNPVSYQIIPYAGGTHPVAKGAQFAPDEWIYHR
  LSFMDKQLWVTRYHPGERFPEGKYPNRSTHDTGLGQYSKDNESLDNTDAVVWMTTGTTHV
  ARAEEWPIMPTEWVHTLLKPWNFFDETPTLGALKKDK
• Function: This enzyme can oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (ecj01110)
  Glycine, serine and threonine metabolism (ecj00260)
  Metabolic pathways (ecj01100)
  Phenylalanine metabolism (ecj00360)
  Tyrosine metabolism (ecj00350)
  beta-Alanine metabolism (ecj00410)

Molecular Interaction Atlas (MIA) of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1]

References

• [1] Mechanistic elucidation of amphetamine metabolism by tyramine oxidase from human gut microbiota using molecular dynamics simulations. J Cell Biochem. 2019 Jan 30.