Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEDY9F6)

• DME Name: Cellobiose 2-epimerase (CE)
• Synonyms: Cellobiose epimerase; CS-HRCE; Caob-CE; B15CE; BfCE; CE; CE-NE1; CsCE; ce13
• Gene Name: ce13
• UniProt ID: CEEP_EUBCE
• INTEDE ID: DME1133
• EC Number:
  EC: 5.1.3.11
  Isomerase
  Racemase/epimerase
  Carbohydrate racemase/epimerase
  EC: 5.1.3.11
• Lineage:
  Species: Eubacterium cellulosolvens
  Kingdom: Bacteria
  Phylum: Firmicutes
  Class: Clostridia
  Order: Clostridiales
  Family: Eubacteriaceae
  Genus: Eubacterium
  Species: Eubacterium cellulosolvens
  Subspecies: Eubacterium cellulosolvens NE13
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MKNEVVYKQLTEKILPFWNAMRDDENGGFYGYMSEDLHIDDHADKGCILNSRILWFYSTA
  YMYLQDEKLLDNAKHAFEFLKTYCFDPMCGGIFWSVRYNGKPADTTKHTYNQAFAIYALS
  AYYEATGSIEAIAIAEIIYEKIEDTMRDTKGYLEAFTRDFRPADNDKLSENGVMAERTMN
  TLLHIIEAYSALVHALRKKVADPAKGDVRDELFMNVVENKLAAALELMRDKFYNSDRHRL
  DVFFDKEYESLIDLTSYGHDIEASWLLEWAAGILDDEEITESLHPISSDLVEKVYKEAFD
  GHSIVNECEDGDVNTDRIWWVEAESVLGFLKAFEREGKEEYRKAAHEILAFILDKQVDKR
  EGSEWFEMLKEDGTPCHKPMVREWKCPYHNGRMCLEILKSGIEIG
• Function: This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety. Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) and epimerizes lactose to epilactose.

Molecular Interaction Atlas (MIA) of This DME

2 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[1]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[1]

References

• [1] Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.