Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEE8WXK)

• DME Name: Beta-glucosidase (bglA)
• Synonyms: Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BADO_0074; ERS852419_00699; LU08_00495
• Gene Name: bglA
• UniProt ID: A0A076JJU4_BIFAD
• INTEDE ID: DME1847
• EC Number:
  EC: 3.2.1.21
  Hydrolases
  Glycosylase
  O/S-glycosyl compound glycosidase
  EC: 3.2.1.21
• Lineage:
  Species: Bifidobacterium adolescentis
  Kingdom: Bacteria
  Phylum: Actinobacteria
  Class: Actinobacteria
  Order: Bifidobacteriales
  Family: Bifidobacteriaceae
  Genus: Bifidobacterium
  Species: Bifidobacterium adolescentis
• Tissue Distribution: Primarily distributed in human gut.
• Sequence:
  MTLTFPQDFTFGTATAAYQIEGAVTEDGRCPSIWDTFSHTPGATIAGDTGDVATDSYHRW
  REDLALLKDLGVDAYRFSIAVPRIISTPDGVPNEKGLDFYEGVVDALLEAGIKPVVTLYH
  WDLPQYLGDEGGWLNRRTAYALADYAGIVAKRLGDRVDTWTTLNEPWCSSYLSYGAKEHA
  PGLGLGPGAFPAVHHLNLAHGLMTQAVRAEVGDKAKCSVTLNLQFNRGDADACHRLDLIS
  NRAFLDPMLRGRYPDELFSITKGICDWDFIQSGDLELIHQPIDVLGINYYSTNRVAMSDR
  PQFPQSTEASTAPGASDVDWLPTEGPHTDMGWNIDPDGLHDLLVRVHDNYPEVDLVVTEN
  GMACKDQLTVNEDGTKSVHDPDRIDYLKRHFAAAKRAIDEGVPLTGYFVWSLLDNFEWYF
  GYAKRFGITYVDYATQERIPKDSFMWYRDFLASRKG
• Function: This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
• KEGG Pathway:
  Biosynthesis of secondary metabolites (badl01110)
  Cyanoamino acid metabolism (badl00460)
  Metabolic pathways (badl01100)
  Starch and sucrose metabolism (badl00500)

Molecular Interaction Atlas (MIA) of This DME

1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ginsenoside Rb1	DMF70AB	N. A.	N. A.	Investigative	[1]

References

• [1] Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.