Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEEAL81)

• DME Name: Beta-lactamase (blaB)
• Synonyms: Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase SHV-2; SHV-2A; bla; shv2
• Gene Name: bla
• UniProt ID: BLA2_KLEPO
• INTEDE ID: DME1024
• EC Number:
  EC: 3.5.2.6
  Hydrolases
  Carbon-nitrogen hydrolase
  Cyclic amide hydrolase
  EC: 3.5.2.6
• Lineage:
  Species: Klebsiella variicola
  Kingdom: Bacteria
  Phylum: Proteobacteria
  Class: Gammaproteobacteria
  Order: Enterobacterales
  Family: Enterobacteriaceae
  Genus: Klebsiella
  Species: Klebsiella variicola
  Subspecies: Klebsiella variicola subsp. Ozaenae
• Tissue Distribution: Primarily distributed in human lung.
• Sequence:
  MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADE
  RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
  AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
  SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGASERGARG
  IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
• Function: This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.

Molecular Interaction Atlas (MIA) of This DME

5 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[1]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[1], [2]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[1], [2]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[1]
Cefpirome	DMJKWPZ	N. A.	N. A.	Phase 4	[2]

References

• [1] Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24.
• [2] Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5.