Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEEN9RD)

DME Name Alcohol dehydrogenase class-I beta (ADH1B)
Synonyms Alcohol dehydrogenase 1B; Alcohol dehydrogenase subunit beta; All-trans-retinol dehydrogenase [NAD(+)] ADH1B; ADH1B; ADH2
Gene Name ADH1B
UniProt ID
ADH1B_HUMAN
INTEDE ID
DME0128
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Gene ID
125
EC Number EC: 1.1.1.105
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.105
Lineage Species: Homo sapiens
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Sequence
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVT
PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNP
RGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
YGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATE
CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQ
NLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGF
DLLHSGKSIRTVLTF
Function
This enzyme catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro it can also catalyzes the NADH-dependent reduction of all-trans- retinal and its derivatives such as all-trans-4-oxoretinal.
KEGG Pathway
Chemical carcinogenesis (hsa05204 )
Drug metabolism - cytochrome P450 (hsa00982 )
Fatty acid degradation (hsa00071 )
Glycolysis / Gluconeogenesis (hsa00010 )
Metabolic pathways (hsa01100 )
Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
Retinol metabolism (hsa00830 )
Tyrosine metabolism (hsa00350 )
Reactome Pathway
Ethanol oxidation (R-HSA-71384 )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Approved Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [1]
NADH DM5NM6E Parkinson disease 8A00.0 Approved [2]

Molecular Expression Atlas (MEA) of This DME

Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This DME
Disease Name ICD 11 Studied Tissue p-value Fold-Change Z-score
Acute myelocytic leukaemia 2B33.1 Bone marrow 2.06E-01 -1.43E-02 -4.01E-02
Alopecia ED70 Skin from scalp 5.41E-02 3.75E-01 5.67E-01
Alzheimer's disease 8A20 Entorhinal cortex 2.61E-03 7.98E-02 3.20E-01
Ankylosing spondylitis FA92.0 Pheripheral blood 1.80E-01 3.80E-02 4.04E-01
Aortic stenosis BB70 Calcified aortic valve 7.86E-02 -1.79E+00 -1.07E+00
Apnea 7A40 Hyperplastic tonsil 2.93E-01 5.89E-02 4.63E-01
Arthropathy FA00-FA5Z Peripheral blood 1.77E-02 5.51E-02 8.86E-01
Asthma CA23 Nasal and bronchial airway 1.97E-03 -1.49E-01 -5.91E-01
Atopic dermatitis EA80 Skin 1.53E-05 -9.31E-01 -1.67E+00
Autism 6A02 Whole blood 5.82E-01 -3.60E-02 -3.93E-01
Autoimmune uveitis 9A96 Peripheral monocyte 3.62E-02 -1.85E-01 -1.18E+00
Autosomal dominant monocytopenia 4B04 Whole blood 5.13E-04 9.23E-02 1.15E+00
Bacterial infection of gingival 1C1H Gingival tissue 7.09E-01 1.96E-02 8.88E-02
Batten disease 5C56.1 Whole blood 1.40E-01 3.29E-02 6.08E-01
Behcet's disease 4A62 Peripheral blood 7.08E-01 4.56E-02 3.35E-01
Bipolar disorder 6A60-6A6Z Prefrontal cortex 1.53E-01 5.85E-02 3.32E-01
Bladder cancer 2C94 Bladder tissue 5.51E-10 -4.91E+00 -1.02E+01
Breast cancer 2C60-2C6Z Breast tissue 7.21E-105 -4.55E+00 -2.38E+00
Cardioembolic stroke 8B11.20 Whole blood 4.87E-01 2.00E-02 2.05E-01
Cervical cancer 2C77 Cervical tissue 5.22E-01 -2.92E-02 -1.17E-01
Childhood onset rheumatic disease FA20.Z Peripheral blood 3.69E-01 8.18E-03 7.44E-02
Chronic hepatitis C 1E51.1 Whole blood 4.98E-01 -7.12E-02 -5.72E-01
Chronic obstructive pulmonary disease CA22 Lung tissue 1.22E-02 -2.19E-01 -6.31E-01
Chronic obstructive pulmonary disease CA22 Small airway epithelium 2.54E-01 -2.76E-02 -7.21E-02
Chronic rhinosinusitis CA0A Sinus mucosa tissue 3.81E-02 -1.20E+00 -1.15E+00
Colon cancer 2B90 Colon tissue 4.82E-78 -2.63E+00 -3.17E+00
Coronary artery disease BA80-BA8Z Peripheral blood 6.20E-01 -5.60E-02 -5.20E-01
Diffuse large B-cell lymphoma 2A81 Tonsil tissue 9.96E-01 -1.91E-02 -2.06E-01
Endometriosis GA10 Endometrium tissue 7.06E-04 4.50E-01 3.98E-01
Familial hypercholesterolemia 5C80.00 Peripheral blood 1.94E-01 -6.51E-02 -8.74E-01
Familial hypercholesterolemia 5C80.00 Whole blood 6.54E-02 -4.83E-02 -4.25E-01
Gastric cancer 2B72 Gastric tissue 1.53E-01 -2.32E+00 -1.67E+00
Glioblastopma 2A00.00 Nervous tissue 7.53E-05 -1.08E-01 -1.78E-01
Glioma 2A00.0Y-2A00.0Z Brain stem tissue 9.10E-01 -1.57E-01 -7.54E-01
Glioma 2A00.0Y-2A00.0Z White matter tissue 1.23E-01 -2.73E-01 -8.45E-01
Head and neck cancer 2D42 Head and neck tissue 4.71E-08 -1.04E+00 -6.99E-01
HIV-associated neurocognitive impairment 8A2Y-8A2Z White matter tissue 6.13E-01 -5.01E-03 -2.53E-02
Huntington's disease 8A01.10 Whole blood 8.55E-01 3.55E-02 3.23E-01
Idiopathic pulmonary fibrosis CB03.4 Lung tissue 1.60E-01 -7.51E-01 -1.06E+00
Immunodeficiency 4A00-4A20 Peripheral blood 2.48E-01 6.38E-02 6.28E-01
Influenza 1E30 Whole blood 2.64E-01 6.88E-02 6.10E-01
Interstitial cystitis GC00.3 Bladder tissue 8.17E-01 2.80E-01 4.27E-01
Intracranial aneurysm 8B01.0 Intracranial artery 8.46E-03 -1.12E+00 -1.40E+00
Irritable bowel syndrome DD91.0 Rectal colon tissue 1.49E-03 -1.38E-01 -5.13E-01
Ischemic stroke 8B11 Peripheral blood 1.44E-01 5.06E-02 5.44E-01
Juvenile idiopathic arthritis FA24 Peripheral blood 4.14E-02 6.16E-02 2.30E-01
Lateral sclerosis 8B60.4 Skin 2.20E-01 2.71E-02 4.20E-01
Lateral sclerosis 8B60.4 Cervical spinal cord 9.63E-02 -8.04E-02 -2.22E-01
Liver cancer 2C12.0 Liver tissue 7.46E-50 -1.79E+00 -4.29E+00
Liver failure DB99.7-DB99.8 Liver tissue 1.92E-06 -3.38E+00 -6.42E+00
Lung cancer 2C25 Lung tissue 1.23E-269 -3.91E+00 -6.78E+00
Lupus erythematosus 4A40 Whole blood 4.81E-01 -1.27E-02 -6.03E-02
Major depressive disorder 6A70-6A7Z Hippocampus 8.67E-01 3.48E-02 1.63E-01
Major depressive disorder 6A70-6A7Z Whole blood 9.84E-02 3.72E-02 2.34E-01
Melanoma 2C30 Skin 5.15E-04 -3.06E+00 -1.56E+00
Multiple myeloma 2A83.1 Peripheral blood 9.75E-02 7.34E-02 8.36E-01
Multiple myeloma 2A83.1 Bone marrow 1.50E-03 -3.27E-01 -1.85E+00
Multiple sclerosis 8A40 Plasmacytoid dendritic cells 6.29E-01 -4.42E-02 -3.36E-01
Myelodysplastic syndrome 2A36-2A3Z Bone marrow 5.60E-01 2.52E-02 2.68E-01
Myelofibrosis 2A20.2 Whole blood 2.13E-01 5.73E-02 4.94E-01
Myocardial infarction BA41-BA50 Peripheral blood 7.81E-02 2.41E-02 7.52E-02
Myopathy 8C70.6 Muscle tissue 2.58E-01 1.74E-01 4.05E-01
Neonatal sepsis KA60 Whole blood 7.96E-01 6.86E-03 4.99E-02
Neuroectodermal tumour 2A00.11 Brain stem tissue 2.28E-04 -1.19E+00 -1.79E+00
Non-alcoholic fatty liver disease DB92 Liver tissue 3.07E-01 1.73E-01 3.97E-01
Obesity related type 2 diabetes 5A11 Omental adipose tissue 5.12E-01 -1.97E-01 -1.16E+00
Olive pollen allergy CA08.00 Peripheral blood 3.91E-02 1.20E-01 1.80E+00
Oral cancer 2B6E Oral tissue 2.88E-05 -2.51E+00 -1.48E+00
Osteoarthritis FA00-FA0Z Synovial tissue 5.11E-02 -1.93E+00 -1.20E+00
Osteoporosis FB83.1 Bone marrow 2.62E-01 -1.59E-01 -2.02E-01
Ovarian cancer 2C73 Ovarian tissue 2.89E-03 -2.78E+00 -1.83E+00
Pancreatic cancer 2C10 Pancreas 2.46E-03 -1.10E+00 -8.63E-01
Parkinson's disease 8A00.0 Substantia nigra tissue 9.31E-02 1.42E-01 6.88E-01
Pediatric respiratory syncytial virus infection CA40.11 Peripheral blood 1.80E-02 -6.62E-02 -8.80E-01
Pituitary cancer 2D12 Pituitary tissue 1.77E-05 -2.23E+00 -2.42E+00
Pituitary gonadotrope tumour 2D12 Pituitary tissue 5.90E-06 -2.40E+00 -3.18E+00
Polycystic ovary syndrome 5A80.1 Vastus lateralis muscle 6.56E-01 6.98E-02 2.02E-01
Polycythemia vera 2A20.4 Whole blood 1.57E-07 1.30E-01 1.06E+00
Pompe disease 5C51.3 Biceps muscle 2.93E-01 -3.93E-01 -1.10E+00
Preterm birth KA21.4Z Myometrium 1.92E-03 1.87E+00 3.24E+00
Prostate cancer 2C82 Prostate 3.38E-03 -7.68E-01 -4.26E-01
Psoriasis EA90 Skin 1.00E-19 -1.14E+00 -1.39E+00
Rectal cancer 2B92 Rectal colon tissue 2.46E-05 -3.46E+00 -5.15E+00
Renal cancer 2C90-2C91 Kidney 1.31E-03 -2.86E+00 -2.09E+00
Retinoblastoma 2D02.2 Uvea 1.81E-01 -6.02E-02 -9.29E-01
Rheumatoid arthritis FA20 Synovial tissue 8.57E-04 -3.03E+00 -2.50E+00
Rhinovirus infection CA42.1 Nasal epithelium tissue 3.25E-01 -3.99E-02 -5.07E-01
Schizophrenia 6A20 Prefrontal cortex 2.19E-01 2.00E-02 8.14E-02
Schizophrenia 6A20 Superior temporal cortex 8.73E-02 9.89E-02 7.83E-01
Scleroderma 4A42.Z Whole blood 5.23E-02 4.66E-02 5.49E-01
Seizure 8A60-8A6Z Whole blood 6.30E-02 -5.20E-02 -5.20E-01
Sensitive skin EK0Z Skin 6.03E-01 1.37E-02 2.89E-02
Sepsis with septic shock 1G41 Whole blood 3.98E-05 5.46E-02 3.16E-01
Shwachman-Diamond syndrome 3A70.0 Bone marrow 1.37E-01 1.19E-01 5.49E-01
Sickle cell disease 3A51.0-3A51.3 Peripheral blood 4.93E-02 5.97E-02 7.34E-01
Simpson golabi behmel syndrome LD2C Adipose tissue 2.72E-02 -3.66E-01 -2.04E+00
Sjogren's syndrome 4A43.2 Salivary gland tissue 1.96E-01 1.49E+00 1.42E+00
Skin cancer 2C30-2C3Z Skin 8.31E-154 -4.65E+00 -4.52E+00
Thrombocythemia 3B63 Whole blood 1.40E-06 1.72E-01 1.42E+00
Thrombocytopenia 3B64 Whole blood 4.01E-01 3.74E+00 1.64E+00
Thyroid cancer 2D10 Thyroid 6.84E-63 -2.46E+00 -3.84E+00
Tibial muscular dystrophy 8C75 Muscle tissue 3.21E-01 6.54E-01 7.22E-01
Tuberous sclerosis complex LD2D.2 Perituberal tissue 7.74E-01 1.62E-02 1.79E-01
Type 2 diabetes 5A11 Liver tissue 1.73E-01 1.32E-01 1.06E+00
Ureter cancer 2C92 Urothelium 2.16E-01 -5.76E-02 -4.60E-01
Uterine cancer 2C78 Endometrium tissue 5.37E-01 -1.02E-01 -8.48E-02
Vitiligo ED63.0 Skin 3.16E-01 6.88E-02 8.12E-02
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⏷ Show the Full List of DME Expression Under 107 Diseases

References

1 Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25.
2 Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12.