Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEFEVNH)

DME Name	Beta-lactamase (blaB)
Synonyms	Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase superfamily domain; NCTC12948_00659
Gene Name	blaB
UniProt ID	A0A381DV31_9FLAO
INTEDE ID	DME1326
EC Number	EC: 3.5.2.6 Hydrolases Carbon-nitrogen hydrolase Cyclic amide hydrolase EC: 3.5.2.6
Lineage	Species: Capnocytophaga granulosa Kingdom: Bacteria Phylum: Bacteroidetes Class: Flavobacteriia Order: Flavobacteriales Family: Flavobacteriaceae Genus: Capnocytophaga Species: Capnocytophaga granulosa
Tissue Distribution	Primarily distributed in human oral cavity.
Sequence	MKYTFRTFFCGMGDCIFLMLENGCHTLNIMVDCGKYIDEIDNFVKTELKNKIDYLIVTHI DNDHINGLITMLTKNSDLIIGNIIYNCYQRLIKNAIPWTDKMTENVSRLYGKLPIVIDMI SQDINEEKAVTLAECILRKEEWNRTWQREYVTDESPAIQLANNMGRIIFLSPSQAALDQL DKKYRKLFWQQLYKQKEEEYDKEETIYEALMRIAQLDEDEEIKEENVNDCTINEHTLKQY ACQSLSKMDDNNMASIAFVWEHQGHRILFMGDADPTQVSKAIEEAYKDETKPIIFDLIKV SHHGSAHSTSKELMNMADSERFFFTGGAKERPSLQTLGRIITNPLPDGIEYRDIRYNRHN VILKKLADLSVEEKNSLHIKVNDNQNSYEFSY
Function	This enzyme hydrolyzes beta-lactam.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[1]
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References

1	High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4.