Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEFKSVZ)
| DME Name | Catechol-2,3-dioxygenase (caD) | ||||
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| Synonyms | Catechol dioxygenase; Catechol 2,3-dioxygenase; caD; cado; DZB84_00060 | ||||
| Gene Name | DZB84_00060 | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.13.11.2 | ||||
| Lineage | Species: Bacillus pumilus | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MSNFDVAQLAHVELYSPKPEETLKFFTDYLGLQISAREGQSVYLRAYEDFYHHTLKITEA
KEAGMAHTAWRASSEAALYQRVQSLEKSGYGKGWIEGDLGHGAAYQFQTPDGHNMEILWN VEYYRAPEDQKTMLKSRPQKRPNIGIPARRLDHINLMCGNVTQNKQFMADELGFKLRENI IMNDGAEMGAWMSVSPLVHEIALMGDQSGEKGRFHHVAYWYGYPQHLMDLADLLVENGIE IEAGPGKHGISQAYFMYVFEPGGNRVELFGDSGYLILDPDWKTITWKEEELDKGIIWYGS PLPQEYFIYGTPDRSSVKVK |
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| Function | This enzyme initiates the meta-cleavage pathway of catechol degradation and requires FeII. | ||||
Molecular Interaction Atlas (MIA) of This DME
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1 Approved Drug(s) Metabolized by This DME
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