General Information of Drug-Metabolizing Enzyme (DME) (ID: DEGBVKJ)

DME Name Cellobiose 2-epimerase (CE)
Synonyms Cellobiose epimerase; CS-HRCE; Caob-CE; B15CE; BfCE; CE; CE-NE1; CsCE; Cphy_2262
Gene Name CE
UniProt ID
A9KK53_LACP7
INTEDE ID
DME1132
EC Number EC: 5.1.3.11
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.11
Lineage Species: Lachnoclostridium phytofermentans
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Lachnoclostridium
Species: Lachnoclostridium phytofermentans
Tissue Distribution Primarily distributed in human gut.
Sequence
MGNYKQMKELAKAHLSEVVIPFWNKLKDEENGGFYGYLDYDLQLDKKAVKGCILNSRILW
FYSNAYLTLGEEGLLSYAKHAYEFLKNHCYDQTYGGIYWSLNYDGSTYDTTKHTYNQAFA
VYALSSYYFATKDEEAINLAKSIIGIMEKKCTDSFGYLEAFDRDFLPIDNELLSENGVIA
HKTMNTLLHVFEAYTEYYRVTGDMEIKERLMRMLDIIQIKVYNPNLHRQEVFFDVYMNSI
LDLHSYGHDIEAAWLIDRGLDVLKEPKYDYLLKPITKDLTNQIYQTAYQDHSLLNESEKG
KVNTSRIWWVQAEAVVGFLNGYENDRNETRYYEAATDIFQFILENVHDKRTGSEWFWEVD
KEGKPFNKKPIVEPWKCPYHNGRMCFEILRREI
Function
This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety. Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DME
2 Clinical Trial Drug(s) Metabolized by This DME
Drug Name Drug ID Indication ICD 11 Highest Status REF
Maltose DMH0ROP N. A. N. A. Phase 1/2 [1]
Lactose DMO4GPK Discovery agent N.A. Phase 1 [1]

References

1 Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.