| DME Name |
UDP-glucuronosyltransferase 2A1 (UGT2A1)
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| Synonyms |
UDP-glucuronosyltransferase family 2 member A1; UDPGT 2A1; UGT2A1; UGT2A2; OMIM: 604716; MGI: 2149905; HomoloGene: 136808; GeneCards: UGT2A1 |
| Gene Name |
UGT2A1
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| UniProt ID |
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| INTEDE ID |
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| 3D Structure |
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| Gene ID |
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| EC Number |
EC: 2.4.1.17
- Transferase
- Glycosyltransferases
- Hexosyltransferase
- EC: 2.4.1.17
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| Lineage |
Species: Homo sapiens
- Kingdom: Metazoa
- Phylum: Chordata
- Class: Mammalia
- Order: Primates
- Family: Hominidae
- Genus: Homo
- Species: Homo sapiens
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| Sequence |
MLNNLLLFSLQISLIGTTLGGNVLIWPMEGSHWLNVKIIIDELIKKEHNVTVLVASGALF
ITPTSNPSLTFEIYRVPFGKERIEGVIKDFVLTWLENRPSPSTIWRFYQEMAKVIKDFHM
VSQEICDGVLKNQQLMAKLKKSKFEVLVSDPVFPCGDIVALKLGIPFMYSLRFSPASTVE
KHCGKVPYPPSYVPAVLSELTDQMSFTDRIRNFISYHLQDYMFETLWKSWDSYYSKALGR
PTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKN
GVVVFSLGSMVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDL
LGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS
VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHD
LTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGKKKKRE
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| Function |
This enzyme catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. And it is important in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
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| KEGG Pathway |
- Ascorbate and aldarate metabolism (hsa00053 )
- Chemical carcinogenesis (hsa05204 )
- Drug metabolism - cytochrome P450 (hsa00982 )
- Drug metabolism - other enzymes (hsa00983 )
- Metabolic pathways (hsa01100 )
- Metabolism of xenobiotics by cytochrome P450 (hsa00980 )
- Pentose and glucuronate interconversions (hsa00040 )
- Porphyrin and chlorophyll metabolism (hsa00860 )
- Retinol metabolism (hsa00830 )
- Steroid hormone biosynthesis (hsa00140 )
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| Reactome Pathway |
- Glucuronidation (R-HSA-156588 )
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