General Information of Drug (ID: DMWLFGO)

Drug Name
Methyltestosterone
Synonyms Android (TN)
Indication
Disease Entry ICD 11 Status REF
Advanced cancer 2A00-2F9Z Approved [1]
Hormone deficiency 5A61.1 Approved [1]
Hot flushes GA30 Approved [1]
Hypogonadism 5A61.0 Approved [1]
Hypogonadotropic hypogonadism N.A. Approved [1]
Multiple sclerosis 8A40 Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Hypogonadism, male N.A. Investigative [1]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 302.5
Logarithm of the Partition Coefficient (xlogp) 3.4
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
ADMET Property
Elimination
The elimination of drug is 90% via urine and 10% via feces []
Half-life
The concentration or amount of drug in body reduced by one-half in 6 - 8 hours [3]
Metabolism
The drug is metabolized via the hepatic []
Chemical Identifiers
Formula
C20H30O2
IUPAC Name
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Canonical SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C)O)C
InChI
InChI=1S/C20H30O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h12,15-17,22H,4-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/m1/s1
InChIKey
GCKMFJBGXUYNAG-HLXURNFRSA-N
Cross-matching ID
PubChem CID
6010
ChEBI ID
CHEBI:27436
CAS Number
58-18-4
DrugBank ID
DB06710
TTD ID
D0Z1XD
INTEDE ID
DR1064
ACDINA ID
D00421
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [4]
UDP-glucuronosyltransferase 2A1 (UGT2A1) DEGKRXT UD2A1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) OTTG0NFD S5A2_HUMAN Gene/Protein Processing [6]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [7]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [8]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Protein Interaction/Cellular Processes [9]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Gene/Protein Processing [10]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Gene/Protein Processing [10]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Methyltestosterone (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [11]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [12]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Methyltestosterone and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [13]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Cannabidiol. Epileptic encephalopathy [8A62] [14]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Brentuximab vedotin. Hodgkin lymphoma [2B30] [15]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Methyltestosterone and Teriflunomide. Hyper-lipoproteinaemia [5C80] [16]
BMS-201038 DMQTAGO Major Increased risk of hepatotoxicity by the combination of Methyltestosterone and BMS-201038. Hyper-lipoproteinaemia [5C80] [17]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [18]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Methyltestosterone and Idelalisib. Mature B-cell leukaemia [2A82] [19]
Carfilzomib DM48K0X Major Additive thrombogenic effects by the combination of Methyltestosterone and Carfilzomib. Multiple myeloma [2A83] [11]
Insulin degludec DMPL395 Moderate Increased risk of hypoglycemia by the combination of Methyltestosterone and Insulin degludec. Type-1/2 diabete [5A10-5A11] [20]
⏷ Show the Full List of 11 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Ferrosoferric oxide E00231 14789 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
⏷ Show the Full List of 10 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Methyltestosterone 10 mg capsule 10 mg Oral Capsule Oral
Methyltestosterone 10 mg tablet 10 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Methyltestosterone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6945).
3 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
4 Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites. J Chromatogr B Biomed Sci Appl. 1999 Nov 26;735(1):73-83.
5 Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus. Environ Toxicol Pharmacol. 2014 May;37(3):1157-68.
6 Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells. Toxicol In Vitro. 2007 Apr;21(3):502-8.
7 Development and pre-validation of an in vitro transactivation assay for detection of (anti)androgenic potential compounds using 22Rv1/MMTV cells. Reprod Toxicol. 2016 Apr;60:156-66. doi: 10.1016/j.reprotox.2016.02.006. Epub 2016 Feb 8.
8 Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation. Toxics. 2023 Dec 4;11(12):986. doi: 10.3390/toxics11120986.
9 Cell viability and PSA secretion assays in LNCaP cells: a tiered in vitro approach to screen chemicals with a prostate-mediated effect on male reproduction within the ReProTect project. Reprod Toxicol. 2010 Aug;30(1):25-35. doi: 10.1016/j.reprotox.2010.03.008. Epub 2010 Apr 2.
10 Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
11 Cerner Multum, Inc. "Australian Product Information.".
12 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
13 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
14 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
16 Canadian Pharmacists Association.
17 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
18 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
19 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
20 Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]