Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DEGLW18)

DME Name	Cellobiose 2-epimerase (CE)
Synonyms	Cellobiose epimerase; CS-HRCE; Caob-CE; B15CE; BfCE; CE; CE-NE1; CsCE; ERS852582_01163
Gene Name	CE
UniProt ID	A0A173SS24_9FIRM
INTEDE ID	DME1128
EC Number	EC: 5.1.3.11 Isomerase Racemase/epimerase Carbohydrate racemase/epimerase EC: 5.1.3.11
Lineage	Species: Faecalibacterium prausnitzii Kingdom: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Ruminococcaceae Genus: Faecalibacterium Species: Faecalibacterium prausnitzii
Tissue Distribution	Primarily distributed in human gut.
Sequence	MSSIKQAAEEMLLQTIIPFWKGLRDEENGGFYGYMDFDLKLDKKAEKGCILNSRILWFFS EAAMLTGRADLAEDARHAYQFFLKNCYDEANGGVYWSCDYTGKPQDTTKHTYNQGFAIYA LSAYYRLTKDPVALTYAKKIFHLIEQHCTDSEGYLEAFTIDWKPESNEKLSENGVMAAKT MNTLLHVFEGYAGLYQASHDPEVGKALRRILDIYEHKIYSPELHRQLVFFDQHYNSIIDL YSYGHDIESSWLIDWGCDLLGDAALSKRIHAINSDLAAHIYKEAYIDHSVVNECDRGKVN TTRVWWVQAESVLGFVNEYNKSGDAKYRDAAADIYHYICNVMVDKRPGSEWFWEVDADGK PSSRKPILEPWKCPYHNGRMCMELIRRNPDVTV
Function	This enzyme catalyzes the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety. Besides, it catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

2 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[1]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[1]
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References

1	Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40.