Details of Drug-Metabolizing Enzyme (DME)
General Information of Drug-Metabolizing Enzyme (DME) (ID: DEGTKHL)
| DME Name | Azoreductase (azoR) | ||||
|---|---|---|---|---|---|
| Synonyms | Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; HSIEG1_1039 | ||||
| Gene Name | azoR | ||||
| UniProt ID | |||||
| INTEDE ID | |||||
| EC Number | EC: 1.7.1.6 | ||||
| Lineage | Species: Enterococcus casseliflavus | ||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Sequence |
MKNVLVVKANNRPDGVSAKMFDTFVENLDRTAVDVVTFDVYAQPMPYIGQTLFEAFGKLA
QEQDLNQEEQELMTVRQDVMNKFAAADTIVFAFPMWNLTIPAALHTFIDYIFQAGFTFSY NEDGSMNQLLKDKEVVLLNARGGVYSGEMSGMESAVTFMEKVFGGMFGMTISDEVIIEGH NADPSKTEEIIAAGLEKVAEAAKKF |
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| Function | This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity. | ||||
Molecular Interaction Atlas (MIA) of This DME
| Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||
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1 Approved Drug(s) Metabolized by This DME
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